| Wine and health: state of proofs and research needs. | |
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MedLine Citation:
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PMID: 19109750 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regular moderate wine consumption is often associated with reduced morbidity and mortality from to a variety of chronic diseases in which inflammation is a root cause. Wine comes in a wide variety of styles that contain quite different ethanol and polyphenol contents. Controversy remains as to whether the alcohol or polyphenols contribute more to the health benefits of regular moderate wine consumption. The variety of wines available to consumers can be expected to affect health differently in accordance with a particular wine's total polyphenolic content and spectrum of individual polyphenols. The overall effect of wine consumption on health depends upon the total amounts consumed, the style and possibly the pattern of consumption. The apparent effect of wine consumption may be modified by the non-wine diet composition of the consumer in that alcohol may appear as the primary component in consumers with high fruit, vegetable and whole grain intakes while phytochemical benefit may become significant in diets where wine is the primary dietary source of phytochemical. In this review, wine polyphenol mechanisms of action will be reviewed in connection with the mechanism the development of atherosclerotic cardiovascular disease (ASCVD). Selected clinical studies published in 2004-2008 were reviewed. Experimental requirements for valid clinical studies, translation of in vitro to in vivo application and areas where additional evidence needs to be developed were identified. |
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Authors:
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R L Walzem |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Inflammopharmacology Volume: 16 ISSN: 0925-4692 ISO Abbreviation: Inflammopharmacology Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-29 Completed Date: 2009-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112626 Medline TA: Inflammopharmacology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 265-71 Citation Subset: IM |
Affiliation:
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Department of Nutrition and Food Science, and Department of Poultry Science, Texas A&M University, Room 100, Kleberg Animal & Food Science Center, College Station, TX 77843-2472, USA. rwalzem@poultry.tamu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking Cardiovascular Diseases / etiology, prevention & control Flavonoids / analysis, metabolism, pharmacology Health* Humans Phenols / analysis, metabolism, pharmacology Wine* / analysis |
| Chemical | |
Reg. No./Substance:
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0/Flavonoids; 0/Phenols; 0/polyphenols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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