Document Detail


Windowed stochastic proton decoupling for in vivo (13)C magnetic resonance spectroscopy with reduced RF power deposition.
MedLine Citation:
PMID:  21769967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To propose a strategy for reducing radiofrequency (RF) power deposition by stochastic proton decoupling based on Rayleigh's theorem.
MATERIALS AND METHODS: Rayleigh's theorem was used to remove frequency components of stochastic decoupling over the 3.90-6.83 ppm range. [2-(13)C] or [2,5-(13) C(2) ]glucose was infused intravenously to anesthetized rats. (13)C labeling of brain metabolites was detected in the carboxylic/amide spectral region at 11.7 T using either the original stochastic decoupling method developed by Ernst or the proposed windowed stochastic decoupling method.
RESULTS: By restricting frequency components of stochastic decoupling to 1.91-3.90 ppm and 6.83-7.60 ppm spectral regions decoupling power deposition was reduced by ≈50%. The proposed windowed stochastic decoupling scheme is experimentally demonstrated for in vivo (13)C MRS of rat brain at 11.7 T.
CONCLUSION: The large reduction in decoupling power deposition makes it feasible to perform stochastic proton decoupling at very high magnetic fields for human brain (13)C MRS studies.
Authors:
Yun Xiang; Jun Shen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Intramural     Date:  2011-07-18
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  34     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-19     Completed Date:  2012-02-02     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  968-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Affiliation:
Molecular Imaging Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892-1527, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism,  pathology*
Brain Mapping
Carbon Isotopes / diagnostic use,  metabolism*
Glucose / metabolism,  pharmacology*
Infusions, Intravenous
Magnetic Resonance Spectroscopy / methods*
Male
Models, Animal
Rats
Sensitivity and Specificity
Stochastic Processes
Grant Support
ID/Acronym/Agency:
ZIA MH002803-08/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Carbon Isotopes; 50-99-7/Glucose
Comments/Corrections

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