| Wind-up of stretch reflexes as a measure of spasticity in chronic spinalized rats: The effects of passive exercise and modafinil. | |
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MedLine Citation:
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PMID: 20932828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spasticity is a common disorder following spinal cord injury that can impair function and quality of life. While a number of mechanisms are thought to play a role in spasticity, the role of motoneuron persistent inward currents (PICs) is emerging as pivotal. The presence of PICs can be evidenced by temporal summation or wind-up of reflex responses to brief afferent inputs. In this study, a combined neurophysiological and novel biomechanical approach was used to assess the effects of passive exercise and modafinil administration on hyper-reflexia and spasticity following complete T-10 transection in the rat. Animals were divided into 3 groups (n=8) and provided daily passive cycling exercise, oral modafinil, or no intervention. After 6weeks, animals were tested for wind-up of the stretch reflex (SR) during repeated dorsiflexion stretches of the ankle. H-reflexes were tested in a subset of animals. Both torque and gastrocnemius electromyography showed evidence of SR wind-up in the transection only group that was significantly different from both treatment groups (p<0.05). H-reflex frequency dependent depression was also restored to normal levels in both treatment groups. The results provide support for the use of passive cycling exercise and modafinil in the treatment of spasticity and provide insight into the possible contribution of PICs. |
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Authors:
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M Kevin Garrison; Charlotte C Yates; Nancy B Reese; Robert D Skinner; Edgar Garcia-Rill |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-13 |
Journal Detail:
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Title: Experimental neurology Volume: 227 ISSN: 1090-2430 ISO Abbreviation: Exp. Neurol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-10 Completed Date: 2011-02-04 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 0370712 Medline TA: Exp Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 104-9 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Center for Translational Neuroscience, Department of Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72035, USA. kgarrison@uca.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Benzhydryl Compounds / therapeutic use* Chronic Disease Disease Models, Animal Electromyography / methods Female H-Reflex / drug effects, physiology Muscle Spasticity / diagnosis, drug therapy*, etiology, rehabilitation* Muscle, Skeletal / drug effects, physiopathology Neuroprotective Agents / therapeutic use* Physical Conditioning, Animal / methods* Random Allocation Rats Rats, Sprague-Dawley Reflex, Stretch / drug effects, physiology* Severity of Illness Index Spinal Cord Injuries / complications, rehabilitation Time Factors Torque |
| Grant Support | |
ID/Acronym/Agency:
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NS062363/NS/NINDS NIH HHS; P20 RR020146-07/RR/NCRR NIH HHS; R01 NS020246-25/NS/NINDS NIH HHS; R15 NS062363-01A1/NS/NINDS NIH HHS; RR016460/RR/NCRR NIH HHS; RR020146/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzhydryl Compounds; 0/Neuroprotective Agents; 68693-11-8/modafinil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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