Document Detail

Wilson's disease. Psychiatric manifestations may be the clinical presentation.
MedLine Citation:
PMID:  8202418     Owner:  NLM     Status:  MEDLINE    
It is important to consider Wilson's disease in patients with psychiatric signs and symptoms who also have abnormal liver function test results or neurologic findings, or both. Thorough evaluation of emotionally disturbed persons, including complete history taking, careful physical examination, and appropriate laboratory profile, generally rules out or arouses suspicion of Wilson's disease during routine screening. Laboratory abnormalities necessitate repeated studies and additional family and personal history taking with emphasis on possible Wilson's disease. Further workup may then be indicated. Prompt recognition and vigorous, consistent treatment can minimize symptoms and tissue damage. Identifying a case of Wilson's disease and seeing clinical aspects improve with appropriate therapy is gratifying.
G H Jackson; A Meyer; S Lippmann
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Postgraduate medicine     Volume:  95     ISSN:  0032-5481     ISO Abbreviation:  Postgrad Med     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-06     Completed Date:  1994-07-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0401147     Medline TA:  Postgrad Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  135-8     Citation Subset:  AIM; IM    
Department of Internal Medicine and Neurology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina.
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MeSH Terms
Clonazepam / therapeutic use
Copper / blood,  urine
Cornea / pathology
Diagnosis, Differential
Hepatolenticular Degeneration / blood,  complications*,  diagnosis,  drug therapy,  urine
Liver Function Tests
Medical History Taking
Mental Disorders / etiology*
Middle Aged
Penicillamine / therapeutic use
Physical Examination
Reg. No./Substance:
1622-61-3/Clonazepam; 52-67-5/Penicillamine; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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