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Willow bark extract (Salicis cortex) for gonarthrosis and coxarthrosis - Results of a cohort study with a control group.
MedLine Citation:
PMID:  18815018     Owner:  NLM     Status:  In-Data-Review    
STUDY OBJECTIVE: The examination of the effectiveness and tolerance of willow bark extract in patients with gonarthrosis and coxarthrosis compared to conventional therapies.
METHODS: In an open, multicentric observational study with reference treatment, 90 patients were treated with a standardised willow bark extract preparation, 41 patients with a standard therapy prescribed by a doctor and 8 patients with a combination of the two. After 3 and finally 6 weeks the effectiveness and tolerance were determined by the doctor (clinical findings, recording of adverse events, global tolerance) and by the patients (WOMAC questions concerning pain and stiffness, questions on general state of health).
RESULTS: A total of 88 patients in the willow bark group and 40 patients in the reference group completed the study. The doctors and patients judged the effectiveness in both groups to be comparable. After 6 weeks the effectiveness of the willow bark extract tended to be assessed as better than in the group undergoing conventional therapy. Also in the subgroup of chronically sick patients (>3 months), after 6 weeks the effectiveness of both forms of treatment was comparable; however, the effect was slower to set in the willow bark group than in the reference group. Doctors and patients assessed the tolerance of the willow bark extract to be better than the conventional therapy. Adverse effects of the drugs did not occur in the willow bark group; one case each of reflux symptoms occurred in the reference group and the
CONCLUSIONS: For treating mild or fairly severe cases of gonarthrosis and coxarthrosis the effect of willow bark extract is comparable to that of standard therapies, without the corresponding side effects having to be accepted.
A-M Beer; T Wegener
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Publication Detail:
Type:  Journal Article     Date:  2008-09-23
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  15     ISSN:  0944-7113     ISO Abbreviation:  Phytomedicine     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2012-05-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  907-13     Citation Subset:  IM    
Section for Naturopathy and Prevention (Department of General Medicine Hattingen-Blankenstein), Ruhr University, Bochum, Germany.
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