Document Detail

William Maddock Bayliss's therapy for wound shock.
MedLine Citation:
PMID:  20973450     Owner:  NLM     Status:  In-Process    
During World War I, military surgeons discovered that patients die from wound shock because their blood pressure falls catastrophically. William Maddock Bayliss produced experimental shock by bleeding anaesthetized cats, which lowers their blood pressure. He restored pressure by infusing salt solution containing enough gum acacia to generate the colloid osmotic pressure ordinarily contributed by the plasma proteins. Ernest Henry Starling had demonstrated that as plasma flows through the capillaries the colloid osmotic pressure of its proteins retains water. From 1917 to 1919 Bayliss and Starling served on the Special Investigation Committee on Surgical Shock and Allied Conditions of the Medical Research Committee. Both gum-saline and blood transfusions were used successfully on wound-shocked soldiers, but we do not know how many were treated, and the effectiveness of whole blood in comparison with gum-saline was not ascertained. Today the colloid osmotic pressure in transfusion solutions is usually provided by dextran or human albumin. Vast quantities are used, but Bayliss's role in the development of this clever biophysical therapy has been almost forgotten.
William Van der Kloott
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Notes and records of the Royal Society of London     Volume:  64     ISSN:  0035-9149     ISO Abbreviation:  Notes Rec R Soc Lond     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505774     Medline TA:  Notes Rec R Soc Lond     Country:  England    
Other Details:
Languages:  eng     Pagination:  271-86     Citation Subset:  QIS    
Department of Physiology and Biophysics, SUNY at Stony Brook, Stony Brook, NY 11793, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hooke's figurations: a figural drawing attributed to Robert Hooke.
Next Document:  Has pharmacy adequately promoted pharmaceutical discoveries to the public?