Document Detail


Will triclosan in toothpaste select for resistant oral streptococci?
MedLine Citation:
PMID:  12667241     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aims of the study were to determine the in vitro sensitivity of triclosan against viridans streptococci and the impact of triclosan on the normal oral microflora. Nine subjects used a triclosan-containing toothpaste for 2 weeks. Saliva samples were collected on days 0 and 14 and were analyzed quantitatively. The minimum inhibitory concentrations of triclosan and of several antimicrobial agents were determined for the streptococci isolated on days 0 and 14. No major changes occurred in the normal oral microflora during the study period. There were no differences in susceptibility between streptococcal strains collected at days 0 and 14 against triclosan or antimicrobial agents. Short-term use of triclosan has no major impact on normal oral microflora or on streptococcal susceptibility of antimicrobial agents. The effects of long-term use should be evaluated.
Authors:
A Sullivan; B Wretlind; C E Nord
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases     Volume:  9     ISSN:  1198-743X     ISO Abbreviation:  Clin. Microbiol. Infect.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-01     Completed Date:  2003-06-03     Revised Date:  2006-11-07    
Medline Journal Info:
Nlm Unique ID:  9516420     Medline TA:  Clin Microbiol Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  306-9     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Pathology and Immunology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Anti-Infective Agents, Local / administration & dosage,  pharmacology*,  therapeutic use
Bacteria, Aerobic / drug effects
Drug Resistance, Bacterial
Humans
Microbial Sensitivity Tests
Oral Hygiene*
Saliva / microbiology*
Streptococcus / classification,  drug effects*,  growth & development
Streptococcus mutans / drug effects,  growth & development
Streptococcus sanguis / drug effects,  growth & development
Toothpaste*
Triclosan / administration & dosage,  pharmacology*
Chemical
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Toothpaste; 3380-34-5/Triclosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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