Document Detail

Will triclosan in toothpaste select for resistant oral streptococci?
MedLine Citation:
PMID:  12667241     Owner:  NLM     Status:  MEDLINE    
The aims of the study were to determine the in vitro sensitivity of triclosan against viridans streptococci and the impact of triclosan on the normal oral microflora. Nine subjects used a triclosan-containing toothpaste for 2 weeks. Saliva samples were collected on days 0 and 14 and were analyzed quantitatively. The minimum inhibitory concentrations of triclosan and of several antimicrobial agents were determined for the streptococci isolated on days 0 and 14. No major changes occurred in the normal oral microflora during the study period. There were no differences in susceptibility between streptococcal strains collected at days 0 and 14 against triclosan or antimicrobial agents. Short-term use of triclosan has no major impact on normal oral microflora or on streptococcal susceptibility of antimicrobial agents. The effects of long-term use should be evaluated.
A Sullivan; B Wretlind; C E Nord
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases     Volume:  9     ISSN:  1198-743X     ISO Abbreviation:  Clin. Microbiol. Infect.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-01     Completed Date:  2003-06-03     Revised Date:  2006-11-07    
Medline Journal Info:
Nlm Unique ID:  9516420     Medline TA:  Clin Microbiol Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  306-9     Citation Subset:  IM    
Department of Microbiology, Pathology and Immunology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Anti-Infective Agents, Local / administration & dosage,  pharmacology*,  therapeutic use
Bacteria, Aerobic / drug effects
Drug Resistance, Bacterial
Microbial Sensitivity Tests
Oral Hygiene*
Saliva / microbiology*
Streptococcus / classification,  drug effects*,  growth & development
Streptococcus mutans / drug effects,  growth & development
Streptococcus sanguis / drug effects,  growth & development
Triclosan / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Toothpaste; 3380-34-5/Triclosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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