| Will seizure control improve by switching from the modified Atkins diet to the traditional ketogenic diet? | |
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MedLine Citation:
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PMID: 21204815 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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It has been reported that children can maintain seizure control when the ketogenic diet (KD) is transitioned to the less-restrictive modified Atkins diet (MAD). What is unknown, however, is the likelihood of additional seizure control from a switch from the MAD to the KD. Retrospective information was obtained from 27 patients who made this dietary change from four different institutions. Ten (37%) patients had ≥10% additional seizure reduction with the KD over the MAD, of which five became seizure-free. The five children who did not improve on the MAD failed to improve when transitioned to the KD. A higher incidence of improvement with the KD occurred for those with myoclonic-astatic epilepsy (70% vs. 12% for all other etiologies, p = 0.004), including all who became seizure-free. These results suggest that the KD probably represents a "higher dose" of dietary therapy than the MAD, which may particularly benefit those with myoclonic-astatic epilepsy. |
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Authors:
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Eric H Kossoff; Jennifer L Bosarge; Maria J Miranda; Adelheid Wiemer-Kruel; Hoon Chul Kang; Heung Dong Kim |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-11-10 |
Journal Detail:
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Title: Epilepsia Volume: 51 ISSN: 1528-1167 ISO Abbreviation: Epilepsia Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-01-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 2496-9 Citation Subset: IM |
Copyright Information:
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Wiley Periodicals, Inc. © 2010 International League Against Epilepsy. |
Affiliation:
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Neurology, The Johns Hopkins University, Baltimore, Maryland, USA. ekossoff@jhmi.edu |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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M01-RR00052/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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