Document Detail


Will periodic intravenous injections of conditioned bone marrow cells effectively reduce atherosclerosis?
MedLine Citation:
PMID:  21740335     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maintenance of healthy arteries requires a balance between injuries to the arterial wall and processes of intrinsic arterial repair. Such repair requires the availability of progenitor cells that are local to the wall itself. Progenitor cells from distant reservoirs like the bone marrow may also contribute to repair. Arterial repair seems to degrade over a lifetime, particularly with risk factors such as smoking and diabetes. Hence, a potential preventive/therapeutic strategy for atherosclerosis could be transfusion of competent bone marrow cells (BMCs) to restore effective repair in the face of arterial injury and depleted endogenous repair reservoirs. The challenge with this strategy has been the reliable collection and/or generation of BMCs that support arterial repair. In this study, we describe a set of experiments to elucidate a method of culturing BMCs that robustly retards atherosclerosis development in apolipoprotein E knockout mice. Identifying such a method would represent an important step in developing cell-based treatments for patients with proclivity for developing atherosclerosis.
Authors:
Xiaohua Song; Qi Ma; Xialin Liu; Pearl Seo; Ed Herderick; Keith Webster; Pascal J Goldschmidt-Clermont; David Seo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-09-22
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  16     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-11-15     Completed Date:  2012-03-09     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Medicine, University of Miami, Florida, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apolipoproteins E / genetics
Atherosclerosis / genetics,  metabolism,  therapy*
Bone Marrow Transplantation*
Cluster Analysis
Disease Models, Animal
Gene Expression Profiling
Gene Expression Regulation
Injections, Intravenous
Mice
Mice, Inbred C57BL
Mice, Knockout
Primary Cell Culture / methods
Treatment Outcome
Grant Support
ID/Acronym/Agency:
K12RR17630/RR/NCRR NIH HHS; R01 HL71536/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins E
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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