| Will periodic intravenous injections of conditioned bone marrow cells effectively reduce atherosclerosis? | |
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MedLine Citation:
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PMID: 21740335 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Maintenance of healthy arteries requires a balance between injuries to the arterial wall and processes of intrinsic arterial repair. Such repair requires the availability of progenitor cells that are local to the wall itself. Progenitor cells from distant reservoirs like the bone marrow, may also contribute to repair. Arterial repair seems to degrade over a lifetime, particularly with risk factors such as smoking and diabetes. Hence, a potential preventive/therapeutic strategy for atherosclerosis could be transfusion of competent bone marrow cells (BMCs) to restore effective repair in the face of arterial injury and depleted endogenous repair reservoirs. The challenge with this strategy has been the reliable collection and/or generation of BMCs that support arterial repair. In this study, we describe a set of experiments to elucidate a method of culturing BMCs that robustly retards atherosclerosis development in apolipoprotein E knockout mice. Identifying such a method would represent an important step in developing cell-based treatments for patients with proclivity for developing atherosclerosis. |
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Authors:
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Xiaohua Song; Qi Ma; Xialin Liu; Pearl Seo; Edward Herderick; Keith A Webster; Pascal J Goldschmidt-Clermont; David Seo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-10 |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: - ISSN: 1557-7716 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Miami School of Medicine, Miami, Florida, United States; xsong@med.miami.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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