Document Detail

Will amitriptyline prevent the "cheese" reaction of monoamine-oxidase inhibitors?
MedLine Citation:
PMID:  6123888     Owner:  NLM     Status:  MEDLINE    
Administration of amitriptyline greatly diminished the pressor response to intravenous tyramine in patients receiving monoamine-oxidase inhibitors (MAOIs). Dothiepin and trimipramine, however, produced little change in sensitivity to tyramine. It is suggested that a combination of amitriptyline and an MAOI, started together in a modest dose that is then increased, may protect patients against the potential dangers of eating tyramine-containing foods. However, because MAOIs allow a high proportion of ingested tyramine to be absorbed into the systemic circulation, patients treated with MAOIs, even in combination with amitriptyline, should not be encouraged to eat foods containing tyramine.
C M Pare; N Kline; C Hallstrom; T B Cooper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-08-26     Completed Date:  1982-08-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  183-6     Citation Subset:  AIM; IM    
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MeSH Terms
Amitriptyline / pharmacology*,  therapeutic use
Blood Pressure / drug effects
Cheese / adverse effects*
Depression / drug therapy
Drug Synergism
Hypertension / chemically induced,  prevention & control*
Injections, Intravenous
Middle Aged
Monoamine Oxidase Inhibitors / pharmacology*,  therapeutic use
Tyramine / administration & dosage,  adverse effects*,  antagonists & inhibitors
Reg. No./Substance:
0/Monoamine Oxidase Inhibitors; 50-48-6/Amitriptyline; 51-67-2/Tyramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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