| Will amitriptyline prevent the "cheese" reaction of monoamine-oxidase inhibitors? | |
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MedLine Citation:
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PMID: 6123888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Administration of amitriptyline greatly diminished the pressor response to intravenous tyramine in patients receiving monoamine-oxidase inhibitors (MAOIs). Dothiepin and trimipramine, however, produced little change in sensitivity to tyramine. It is suggested that a combination of amitriptyline and an MAOI, started together in a modest dose that is then increased, may protect patients against the potential dangers of eating tyramine-containing foods. However, because MAOIs allow a high proportion of ingested tyramine to be absorbed into the systemic circulation, patients treated with MAOIs, even in combination with amitriptyline, should not be encouraged to eat foods containing tyramine. |
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Authors:
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C M Pare; N Kline; C Hallstrom; T B Cooper |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lancet Volume: 2 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1982 Jul |
Date Detail:
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Created Date: 1982-08-26 Completed Date: 1982-08-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 183-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amitriptyline / pharmacology*, therapeutic use Blood Pressure / drug effects Cheese / adverse effects* Depression / drug therapy Drug Synergism Female Humans Hypertension / chemically induced, prevention & control* Injections, Intravenous Male Middle Aged Monoamine Oxidase Inhibitors / pharmacology*, therapeutic use Tyramine / administration & dosage, adverse effects*, antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Monoamine Oxidase Inhibitors; 50-48-6/Amitriptyline; 51-67-2/Tyramine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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