Document Detail


Will amitriptyline prevent the "cheese" reaction of monoamine-oxidase inhibitors?
MedLine Citation:
PMID:  6123888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Administration of amitriptyline greatly diminished the pressor response to intravenous tyramine in patients receiving monoamine-oxidase inhibitors (MAOIs). Dothiepin and trimipramine, however, produced little change in sensitivity to tyramine. It is suggested that a combination of amitriptyline and an MAOI, started together in a modest dose that is then increased, may protect patients against the potential dangers of eating tyramine-containing foods. However, because MAOIs allow a high proportion of ingested tyramine to be absorbed into the systemic circulation, patients treated with MAOIs, even in combination with amitriptyline, should not be encouraged to eat foods containing tyramine.
Authors:
C M Pare; N Kline; C Hallstrom; T B Cooper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-08-26     Completed Date:  1982-08-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  183-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Amitriptyline / pharmacology*,  therapeutic use
Blood Pressure / drug effects
Cheese / adverse effects*
Depression / drug therapy
Drug Synergism
Female
Humans
Hypertension / chemically induced,  prevention & control*
Injections, Intravenous
Male
Middle Aged
Monoamine Oxidase Inhibitors / pharmacology*,  therapeutic use
Tyramine / administration & dosage,  adverse effects*,  antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Monoamine Oxidase Inhibitors; 50-48-6/Amitriptyline; 51-67-2/Tyramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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