| Will Gd-EOB-MRI change the diagnostic algorithm in hepatocellular carcinoma? | |
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MedLine Citation:
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PMID: 20616589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A hepatocyte-specific contrast agent, gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), was approved in Japan in 2008. This contrast agent enhances the blood pool and also is hepatocyte specific: it is taken up by hepatocytes and excreted into the biliary tract. Approximately 50% of the administered dose of Gd-EOB-DTPA is taken up by normal hepatocytes and subsequently excreted into the biliary tract, while the remaining 50% is excreted via the kidney. Hepatocellular uptake is considered to represent passive diffusion mediated by organic anion transporter polypeptide 1 (OATP1), which is expressed on the hepatocyte membrane. Gd-EOB-DTPA-enhanced MRI may offer a breakthrough for the diagnosis of liver tumors, particularly early hepatocellular carcinoma (HCC). The differentiation of dysplastic nodules from early HCC has remained difficult, even for pathologists specialized in liver tumors, but Gd-EOB-DTPA MRI facilitates an objective diagnosis with accuracy close to that of HCC-specialized pathologists. In conclusion, Gd-EOB-DTPA MRI facilitates the diagnosis of hypervascular advanced HCC and the differentiation of early HCC and dysplastic nodules, which used to be difficult, even with CT during arterial portography, and offers a high accuracy rate. Thus, Gd-EOB-DTPA MRI will have a significant impact on diagnostic algorithm for HCC. |
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Authors:
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Masatoshi Kudo |
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Publication Detail:
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Type: Journal Article Date: 2010-07-08 |
Journal Detail:
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Title: Oncology Volume: 78 Suppl 1 ISSN: 1423-0232 ISO Abbreviation: Oncology Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-09 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0135054 Medline TA: Oncology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 87-93 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan. m-kudo @ med.kindai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Carcinoma, Hepatocellular / diagnosis* Contrast Media / diagnostic use* Gadolinium DTPA / diagnostic use* Humans Liver Neoplasms / diagnosis* Magnetic Resonance Imaging |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/gadolinium ethoxybenzyl DTPA; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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