| Wild-type cone photoreceptors persist despite neighboring mutant cone degeneration. | |
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MedLine Citation:
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PMID: 20053919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In many retinal diseases, the malfunction that results in photoreceptor loss occurs only in either rods or cones, but degeneration can progress from the affected cell type to its healthy neighbors. Specifically, in human and mouse models of Retinitis Pigmentosa the loss of rods results in the death of neighboring healthy cones. Significantly less is known about cone-initiated degenerations and their affect on neighboring cells. Sometimes rods remain normal after cone death, whereas other patients experience a loss of scotopic vision over time. The affect of cone death on neighboring cones is unknown. The zebrafish is a cone-rich animal model in which the potential for dying cones to kill neighboring healthy cones can be evaluated. We previously reported that the zebrafish cone phosphodiesterase mutant (pde6c(w59)) displays a rapid death of cones soon after their formation and a subsequent loss of rods in the central retina. In this study we examine morphological changes associated with cone death in vivo in pde6c(w59) fish. We then use blastulae transplantations to create chimeric fish with a photoreceptor layer of mixed wild-type (WT) and pde6c(w59) cones. We find that the death of inoperative cones does not cause neighboring WT cone loss. The survival of WT cones is independent of transplant size and location within the retina. Furthermore, transplanted WT cones persist at least several weeks after the initial death of dysfunctional mutant cones. Our results suggest a potential for the therapeutic transplantation of healthy cones into an environment of damaged cones. |
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Authors:
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Alaron Lewis; Philip Williams; Owen Lawrence; Rachel O L Wong; Susan E Brockerhoff |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 30 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-07 Completed Date: 2010-02-04 Revised Date: 2011-05-17 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 382-9 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bystander Effect / physiology Cell Death Mutation / physiology* Retinal Cone Photoreceptor Cells / cytology*, physiology* Retinal Degeneration / genetics*, pathology*, physiopathology Zebrafish Zebrafish Proteins / physiology |
| Grant Support | |
ID/Acronym/Agency:
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5F32EY019210/EY/NEI NIH HHS; EY14358/EY/NEI NIH HHS; P30EY01733/EY/NEI NIH HHS; R01 EY018814-01A2/EY/NEI NIH HHS; R01EY018814/EY/NEI NIH HHS; T32EY007031/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Zebrafish Proteins |
| Comments/Corrections | |
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