Document Detail

Wild mushrooms Clitocybe alexandri and Lepista inversa: in vitro antioxidant activity and growth inhibition of human tumour cell lines.
MedLine Citation:
PMID:  20647028     Owner:  NLM     Status:  MEDLINE    
The in vitro antioxidant and growth inhibitory activity of extracts obtained from two Portuguese wild mushrooms (Clitocybe alexandri and Lepista inversa) was studied in human tumour cell lines. The extracts were phenolic (methanolic and ethanolic) and polysaccharidic (boiling water). The antioxidant activity assays included evaluation of radical-scavenging capacity, reducing power and inhibition of lipid peroxidation measured in liposome solutions. Extract-induced cell growth inhibition was measured in four different tumour cell lines (lung, breast, colon and gastric cancer) using the SRB assay. The polysaccharidic extract of L. inversa was the most potent as antioxidant (EC(50)<1.8 ± 0.1mg/ml), while the phenolic ethanolic extract of C. alexandri was the most potent as inhibitor of growth of the studied cancer cell lines (GI(50)<26.0 ± 1.3 μg/ml). Together, these activities indicate that these mushrooms are promising sources of bioactive compounds.
Josiana A Vaz; Sandrina A Heleno; Anabela Martins; Gabriela M Almeida; M Helena Vasconcelos; Isabel C F R Ferreira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-18
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-10     Completed Date:  2010-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2881-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Mountain Research Centre CIMO, Instituto Politécnico de Bragança, Campus de Santa Apolónia, Apartado 1172, 5301-855 Bragança, Portugal.
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MeSH Terms
Agaricales / chemistry*
Antineoplastic Agents / pharmacology*
Antioxidants / pharmacology*
Biphenyl Compounds / chemistry
Cell Line, Tumor
Cell Proliferation / drug effects
Free Radical Scavengers / chemistry
Indicators and Reagents
Phenols / analysis
Picrates / chemistry
Polysaccharides / analysis
Reducing Agents / chemistry
Reference Standards
beta Carotene / chemistry
Reg. No./Substance:
0/Antineoplastic Agents; 0/Antioxidants; 0/Biphenyl Compounds; 0/Free Radical Scavengers; 0/Indicators and Reagents; 0/Phenols; 0/Picrates; 0/Polysaccharides; 0/Reducing Agents; 1898-66-4/2,2-diphenyl-1-picrylhydrazyl; 7235-40-7/beta Carotene

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