Document Detail

Widespread unilateral pain associated with herpes simplex virus infections.
MedLine Citation:
PMID:  18417422     Owner:  NLM     Status:  MEDLINE    
PERSPECTIVE: We suggest that low immunoglobulin subclass levels and certain MHC alleles render the patients susceptible to recurring HSV infections. HSV reactivations and the accompanying inflammatory process cause dysfunction of the central nervous system that manifests as neuropathic pain. Studies using functional brain imaging are needed to clarify this syndrome.
Katariina Kallio-Laine; Mikko Seppänen; Marja-Liisa Lokki; Maija Lappalainen; Irma-Leena Notkola; Ilkka Seppälä; Mika Koskinen; Ville Valtonen; Eija Kalso
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-15
Journal Detail:
Title:  The journal of pain : official journal of the American Pain Society     Volume:  9     ISSN:  1528-8447     ISO Abbreviation:  J Pain     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-09-10     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  100898657     Medline TA:  J Pain     Country:  United States    
Other Details:
Languages:  eng     Pagination:  658-65     Citation Subset:  IM    
Pain Clinic, Department of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, HUS, Helsinki, Finland.
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MeSH Terms
Antibodies, Viral / blood
Biological Markers / blood
Complex Regional Pain Syndromes / blood,  etiology*
Encephalitis, Herpes Simplex / blood,  complications
Enzyme-Linked Immunosorbent Assay
Herpes Genitalis / blood,  complications
Herpes Labialis / blood,  complications
Herpes Simplex / blood,  complications*
Herpes Zoster / blood,  complications
Immunoglobulin G / blood
Magnetic Resonance Imaging
Middle Aged
Pain / blood,  etiology*
Pain Threshold
Simplexvirus / immunology
Reg. No./Substance:
0/Antibodies, Viral; 0/Biological Markers; 0/Immunoglobulin G

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