Document Detail

Widespread role for the flowering-time regulators FCA and FPA in RNA-mediated chromatin silencing.
MedLine Citation:
PMID:  17916737     Owner:  NLM     Status:  MEDLINE    
The RRM-domain proteins FCA and FPA have previously been characterized as flowering-time regulators in Arabidopsis. We show that they are required for RNA-mediated chromatin silencing of a range of loci in the genome. At some target loci, FCA and FPA promote asymmetric DNA methylation, whereas at others they function in parallel to DNA methylation. Female gametophytic development and early embryonic development are particularly susceptible to malfunctions in FCA and FPA. We propose that FCA and FPA regulate chromatin silencing of single and low-copy genes and interact in a locus-dependent manner with the canonical small interfering RNA-directed DNA methylation pathway to regulate common targets.
Isabel Bäurle; Lisa Smith; David C Baulcombe; Caroline Dean
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  318     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-05     Completed Date:  2007-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-12     Citation Subset:  IM    
Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK.
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MeSH Terms
Arabidopsis / genetics*,  growth & development,  metabolism
Arabidopsis Proteins / chemistry,  genetics,  metabolism*
Chromatin / genetics*
DNA Methylation
DNA Transposable Elements
DNA, Plant / metabolism
Flowers / growth & development
Oxidoreductases / genetics
RNA Interference*
RNA, Plant / genetics
RNA, Small Interfering / genetics
RNA-Binding Proteins / chemistry,  genetics,  metabolism*
Transcription, Genetic
Reg. No./Substance:
0/Arabidopsis Proteins; 0/Chromatin; 0/DNA Transposable Elements; 0/DNA, Plant; 0/FPA protein, Arabidopsis; 0/Flowering time control protein FCA, Arabidopsis; 0/RNA, Plant; 0/RNA, Small Interfering; 0/RNA-Binding Proteins; 0/Retroelements; EC 1.-/Oxidoreductases; EC 1.14.99.-/phytoene dehydrogenase

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