| Widespread electroanatomic alterations of right cardiac chambers in patients with myotonic dystrophy type 1. | |
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MedLine Citation:
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PMID: 16426397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Conduction disturbances and arrhythmias characterize the cardiac feature of myotonic dystrophy type 1 (MD1); a myocardial involvement has been suggested as part of the cardiac disease. The aim of our study was to investigate the underlying myocardial alterations using electroanatomic mapping (CARTO) and their possible correlation with genetic and neurological findings. METHODS AND RESULTS: Right atrial and ventricular CARTO maps were obtained in 13 MD1 patients. Thirteen age-matched patients with paroxysmal supraventricular tachycardia and normal heart served as controls. Unipolar voltage (UNI-v), bipolar voltage (BI-v) amplitudes, bipolar potential duration (Bi-dur), and atrial propagation time (A-pt) were measured. UNI-v and BI-v in interatrial septum, anterolateral atrial wall, and right ventricle outflow tract were lower in MD1 patients than controls (P < 0.001). Bi-dur and A-pt were longer in MD1 patients than controls (P < 0.001, P = 0.046, respectively). A significant relationship was documented between CTG triplets and the percentage of Bi-v <0.5 mV in the atrial anteroseptal region (r = 0.6, P = 0.02). CONCLUSIONS: Altered electroanatomic patterns are present in the right cardiac chambers in MD1 patients. Widespread myocardial alterations, not necessarily limited to the conduction system, may support the presence of a cardiac myopathy as part of the disease. |
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Authors:
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Antonio Dello Russo; Gemma Pelargonio; Quintino Parisi; Matteo Santamaria; Loredana Messano; Tommaso Sanna; Michela Casella; Giuseppe De Martino; Roberto De Ponti; Manuela Pace; Vincenzo Giglio; Carolina Ierardi; Paolo Zecchi; Filippo Crea; Fulvio Bellocci |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular electrophysiology Volume: 17 ISSN: 1045-3873 ISO Abbreviation: J. Cardiovasc. Electrophysiol. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-23 Completed Date: 2006-05-04 Revised Date: 2012-02-23 |
Medline Journal Info:
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Nlm Unique ID: 9010756 Medline TA: J Cardiovasc Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 34-40 Citation Subset: IM |
Affiliation:
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Institute of Cardiology, Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmias, Cardiac
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complications,
physiopathology* Body Surface Potential Mapping* Female Heart Atria / physiopathology* Heart Conduction System / physiopathology* Heart Ventricles / physiopathology* Humans Male Middle Aged Myotonic Dystrophy / complications, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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GUP02067//Telethon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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