Document Detail

Widespread electroanatomic alterations of right cardiac chambers in patients with myotonic dystrophy type 1.
MedLine Citation:
PMID:  16426397     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Conduction disturbances and arrhythmias characterize the cardiac feature of myotonic dystrophy type 1 (MD1); a myocardial involvement has been suggested as part of the cardiac disease. The aim of our study was to investigate the underlying myocardial alterations using electroanatomic mapping (CARTO) and their possible correlation with genetic and neurological findings.
METHODS AND RESULTS: Right atrial and ventricular CARTO maps were obtained in 13 MD1 patients. Thirteen age-matched patients with paroxysmal supraventricular tachycardia and normal heart served as controls. Unipolar voltage (UNI-v), bipolar voltage (BI-v) amplitudes, bipolar potential duration (Bi-dur), and atrial propagation time (A-pt) were measured. UNI-v and BI-v in interatrial septum, anterolateral atrial wall, and right ventricle outflow tract were lower in MD1 patients than controls (P < 0.001). Bi-dur and A-pt were longer in MD1 patients than controls (P < 0.001, P = 0.046, respectively). A significant relationship was documented between CTG triplets and the percentage of Bi-v <0.5 mV in the atrial anteroseptal region (r = 0.6, P = 0.02).
CONCLUSIONS: Altered electroanatomic patterns are present in the right cardiac chambers in MD1 patients. Widespread myocardial alterations, not necessarily limited to the conduction system, may support the presence of a cardiac myopathy as part of the disease.
Antonio Dello Russo; Gemma Pelargonio; Quintino Parisi; Matteo Santamaria; Loredana Messano; Tommaso Sanna; Michela Casella; Giuseppe De Martino; Roberto De Ponti; Manuela Pace; Vincenzo Giglio; Carolina Ierardi; Paolo Zecchi; Filippo Crea; Fulvio Bellocci
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  17     ISSN:  1045-3873     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-23     Completed Date:  2006-05-04     Revised Date:  2012-02-23    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-40     Citation Subset:  IM    
Institute of Cardiology, Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy.
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MeSH Terms
Arrhythmias, Cardiac / complications,  physiopathology*
Body Surface Potential Mapping*
Heart Atria / physiopathology*
Heart Conduction System / physiopathology*
Heart Ventricles / physiopathology*
Middle Aged
Myotonic Dystrophy / complications,  physiopathology*
Grant Support

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