Document Detail

Wide variations in energy delivery using an impedance-controlled algorithm in bipolar radiofrequency ablation: evidence against fixed time ablation.
MedLine Citation:
PMID:  22436925     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: : Bipolar radiofrequency ablation recently has been used to replace many of the incisions of the Cox-Maze procedure in the surgical treatment of atrial fibrillation. The unique aspect of this technology is that it uses an algorithm based on changes in tissue conductance to determine the energy required to achieve a transmural lesion instead of relying on predetermined time and/or temperature criteria to determine ablation duration, as with most other ablation technologies. The purpose of this study was to determine variations in the different parameters of ablation needed to create transmural lesions in human atria.
METHODS: : Initial impedance, total energy, temperature, and ablation time were measured in 38 patients undergoing surgery, using an impedance-controlled bipolar radiofrequency device (AtriCure Isolator, Cincinnati, OH). Lesions were categorized into the following groups: right atrial free wall, left atrial free wall, atrium up to mitral valve annulus, atrium up to tricuspid valve annulus, and right or left pulmonary veins.
RESULTS: : There was a wide range of initial impedance (32.3 to 760.7 Ohms), and this correlated with total energy delivered (r = -0.31, P = 0.002). Ablation times varied widely (2.0 to 29.9 seconds) and were longer on left atrial structures than right (P < 0.005) and shortest near the tricuspid annulus (P < 0.001). Mean tissue temperature 1 mm from the electrode was only 45.7 ± 7.8°C (range, 23.7°C to 69.3°C).
CONCLUSIONS: : Bipolar ablation of different atrial structures required widely different amounts of energy and ablation times, probably as the result of the inhomogeneity of atrial geometry and tissue impedance. These data cast doubt on the efficacy of any fixed-time or temperature ablations in the clinical setting.
Spencer J Melby; Andreas Zierer; Rochus K Voeller; Shelly C Lall; Marci S Bailey; Marc R Moon; Richard B Schuessler; Ralph J Damiano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Innovations (Philadelphia, Pa.)     Volume:  2     ISSN:  1556-9845     ISO Abbreviation:  Innovations (Phila)     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2012-03-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101257528     Medline TA:  Innovations (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  -    
From Washington University School of Medicine and Barnes-Jewish Hospital, Division of Cardiothoracic Surgery, Department of Surgery, St. Louis, MO.
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