| Why ribose was selected as the sugar component of nucleic acids. | |
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MedLine Citation:
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PMID: 16569198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During evolution ribose was selected as the exclusive sugar component of nucleic acids. The selection is explained by using molecular models and by eliminating most of the other common sugars by looking at their chemical structure and envisioning how they would fit in a nucleic acid model. Comparisons of sugar pucker conformations and configurations of pentoses indicate that ribose was not randomly selected but the only choice, since beta-D-ribose fits best into the structure of physiological forms of nucleic acids. In other nucleotides containing arabinose, xylose, or lyxose, the C(2)'-OH and/or the C(3)'-OH are above the furanose ring, causing steric interference with the bulky base and the C(5)'-OH group. |
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Authors:
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Gaspar Banfalvi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: DNA and cell biology Volume: 25 ISSN: 1044-5498 ISO Abbreviation: DNA Cell Biol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-29 Completed Date: 2006-04-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9004522 Medline TA: DNA Cell Biol Country: United States |
Other Details:
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Languages: eng Pagination: 189-96 Citation Subset: IM |
Affiliation:
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Department of Animal Anatomy and Physiology, University of Debrecen, Debrecen, Hungary. bgaspar@delfin.unideb.hu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carbohydrate Conformation* Evolution, Chemical* Models, Molecular Molecular Conformation Molecular Structure Nucleic Acid Conformation* Nucleic Acids / chemistry* Ribose / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids; 50-69-1/Ribose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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