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Why randomized clinical trials are important to cardiac surgeons.
MedLine Citation:
PMID:  21918433     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Randomized controlled trials (RCTs) are the gold standard for determining the difference between two alternative treatments and produce level I evidence which serves as the basis of clinical practice guidelines. The purpose of this review is to critically analyze RCTs involving cardiac surgery and demonstrate how RCTs have impacted cardiac surgeons over the past two decades. RECENT FINDINGS: Three recent RCTs may significantly impact the treatment of coronary artery and valvular heart disease: SYNTAX, ART, and PARTNER. These trials are reviewed and their importance to cardiac surgeons is discussed. SUMMARY: Cardiac surgeons must be able to critically analyze RCTs, so that any potential bias can be uncovered which may influence the interpretation of the data and the trial's reported conclusions. It is important for cardiac surgeons to read and understand the major RCTs involving cardiac surgery, as they provide the strongest evidence when choosing between treatment options for patients with cardiac disease.
Authors:
Bradley G Leshnower; Robert A Guyton; John D Puskas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-13
Journal Detail:
Title:  Current opinion in cardiology     Volume:  -     ISSN:  1531-7080     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608087     Medline TA:  Curr Opin Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Cardiothoracic Surgery, Joseph B. Whitehead Department of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
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