Document Detail


Why is the partial oxygen pressure of human tissues a crucial parameter?: Small molecules and hypoxia.
MedLine Citation:
PMID:  21251211     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Oxygen supply and diffusion into tissues are necessary for survival. The oxygen partial pressure (PO(2) ), which is a key component of the physiological state of an organ, results from the balance between oxygen delivery and its consumption. In mammals, oxygen is transported by red blood cells circulating in a well-organized vasculature. Oxygen delivery is dependent on the metabolic requirements and functional status of each organ. Consequently, in a physiologic condition, organ and tissue are characterized by their own unique "tissue normoxia" or "physioxia" status. Tissue oxygenation is severly disturbed during pathological conditions such as cancer, diabetes, coronary heart disease, stroke, etc., which are associated with decrease in PO(2) , ie "hypoxia". In this review we present an array of methods currently used for assessing tissue oxygenation. We show that hypoxia is marked during tumor development and has strong consequences for oxygenation and its influence upon chemotherapy efficiency. Then we compare this to physiological PO(2) values of human organs. Finally we evaluate consequences of "physioxia" on cell activity and its molecular modulations. More importantly we emphasize the discrepancy between in vivo and in vitro tissue and cells oxygen status which can have detrimential effects on experimental outcomes. It appears that the values corresponding to the "physioxia" are ranging between 11% and 1% O(2) while current in vitro experimentations are usually performed in 19.95% O(2) , an artificial context as far as oxygen balance is concerned. It is important to realize that most of the experiments performed in so-called normoxia might be dangerously misleading.
Authors:
Aude Carreau; Bouchra El Hafny-Rahbi; Agata Matejuk; Catherine Grillon; Claudine Kieda
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-20
Journal Detail:
Title:  Journal of cellular and molecular medicine     Volume:  -     ISSN:  1582-4934     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101083777     Medline TA:  J Cell Mol Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
2011.
Affiliation:
Centre de biophysique moléculaire CNRS UPR 4301 Centre de biophysique moléculaire CNRS UPR 4301 Department of Plastic Surgery, Laboratory of Immunology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland Ohio 44195, USA Centre de biophysique moléculaire CNRS UPR 4301 Centre de biophysique moléculaire CNRS UPR 4301 45071 Orléans cedex 2, France.
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