Document Detail

Why is otosclerosis of low prevalence in Japanese?
MedLine Citation:
PMID:  12806287     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study aimed to clarify the reasons why clinical otosclerosis, a very common disease among Caucasians, is not prevalent among Japanese. STUDY DESIGN: The incidence, site, activity, and volume of otosclerotic foci were examined in 1011 temporal bone sections from 507 Japanese individuals. SETTING: This study was prepared at the temporal bone laboratory, Fukushima Medical University, Fukushima. RESULTS: Otosclerotic foci were observed in 2.56% of individuals and in 1.48% of the ears. The most common site of involvement was anterior to the oval window region, but this was only in 38.9% of the ears with otosclerotic foci. The otosclerotic foci were not involved in the stapediovestibular articulation or the endosteal layer of the otic capsule in any ears. An active change of the otosclerotic focus was seen in 33.3% of ears with otosclerosis. The volume of otosclerotic foci at the site anterior to the oval window region was less than 0.8 mm3 in 5 out of 7 ears. CONCLUSION: The incidence of histologic otosclerosis among Japanese seemed to be almost the same as that among Caucasians. Three reasons why clinical otosclerosis was not as prevalent among Japanese as among Caucasians are suggested: low incidence of involvement of foci anterior to the oval window, low activity, and small lesion without involvement of the footplate and/or membranous labyrinth of the inner ear.
Iwao Ohtani; Yohko Baba; Tomoko Suzuki; Chiaki Suzuki; Makoto Kano; Ramesh C Deka
Related Documents :
2224287 - Transition from pre-linguistic to linguistic communication in hearing-impaired infants.
12350057 - Use of clinical indicators to evaluate copc projects.
1867267 - Three years' experience with neonatal screening for duchenne/becker muscular dystrophy:...
12222717 - Neonatal hip instability: results and experiences from ten years of screening with the ...
1923197 - Black-white differences in newborn anthropometric measurements.
576877 - Urine solute excretion in growing low-birth-weight infants.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology     Volume:  24     ISSN:  1531-7129     ISO Abbreviation:  Otol. Neurotol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-06-13     Completed Date:  2003-08-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100961504     Medline TA:  Otol Neurotol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-81     Citation Subset:  IM    
Department of Otolaryngology, Fukushima Medical University, Fukushima, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Deafness / epidemiology,  etiology
Ear, Middle / pathology
Japan / epidemiology
Middle Aged
Otosclerosis / complications,  epidemiology*,  pathology
Temporal Bone / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effects of hyaluronic acid, epidermal growth factor, and mitomycin in an experimental model of a...
Next Document:  The effect of diabetes on sensorineural hearing loss.