Document Detail

Why mitochondria must fuse to maintain their genome integrity.
MedLine Citation:
PMID:  23350575     Owner:  NLM     Status:  Publisher    
Significance: The maintenance of mitochondrial genome integrity is a major challenge for cells in order to sustain energy production by respiration. Recent Advances: Recently, mitochondrial membrane dynamics has emerged as a key process contributing to prevent mitochondrial DNA alterations. Indeed, both fundamental and clinical data suggest that disruption of mitochondrial fusion, related to mutations in the OPA1, MFN2, PINK1 and Parkin genes, leads to the accumulation of mutations in the mitochondrial genome. Critical Issues: We discuss here the possibility that mitochondrial fusion acts as a direct mechanism to prevent the generation of altered mitochondrial DNA and to eliminate mutated deleterious genomes either by trans-complementation or by mitophagy. Future Directions: Finally, we conclude this review with a short evolutionary comparison between the mechanisms involved in mitochondrial and bacterial modes of genome distribution and plasticity, highlighting possible common conserved processes required for the maintenance of their genome integrity, which should inspire our future investigations.
Sara Vidoni; Claudia Zanna; Michela Rugolo; Emmanuelle Sarzi; Guy Lenaers
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-27
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  -     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Cambridge University, Mitochondrial Biology Unit, Cambridge, United Kingdom;
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