Document Detail

Why, how and when do we need to optimize the setting of cardiac resynchronization therapy?
MedLine Citation:
PMID:  19861391     Owner:  NLM     Status:  MEDLINE    
Current cardiac resynchronization therapy (CRT) devices allow manipulation of the atrioventricular (AV) and interventricular (VV) timings in order to maximize the left ventricular (LV) performance. Multiple echocardiographic and non-echocardiographic methods have been proposed to optimize AV and VV intervals but no consensus has been reached on which methodology should preferably be used. Furthermore, different physiologic conditions, such as rest and exercise, may markedly change LV loading conditions, and therefore an optimal setting determined at rest may be different during exercise. The present article reviews current methodologies to optimize AV and VV interval and discuss why, when and how optimization of these delays may be performed based on current evidence. Moreover, an overview of the results of the multicenter trials on AV and VV intervals optimization is provided.
Matteo Bertini; Victoria Delgado; Jeroen J Bax; Nico R L Van de Veire
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  11 Suppl 5     ISSN:  1532-2092     ISO Abbreviation:  Europace     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-28     Completed Date:  2010-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  v46-57     Citation Subset:  IM    
Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
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MeSH Terms
Cardiac Pacing, Artificial / methods*
Exercise / physiology
Heart Atria / physiopathology
Heart Conduction System / physiopathology*
Heart Ventricles / physiopathology
Rest / physiology
Ventricular Dysfunction, Left / physiopathology*,  therapy*

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