| Why does thrombolysis fail? Breaking through the reperfusion ceiling. | |
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MedLine Citation:
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PMID: 9416941 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With best current regimens, thrombolysis may initially fail in 15% to 40% of cases because of hemodynamic or mechanical factors, inadequate fibrinolysis, or failure to lyse platelet-rich thrombi. Pathophysiologic considerations and early experimental and clinical trials suggest that improved conjunctive antiplatelet therapy (as with glycoprotein IIb/IIIa inhibitors) and, possibly, more effective antithrombins (low molecular weight heparins, hirudin) may allow this thrombolysis "ceiling" to be broken and the goal achieved of reperfusion rates closer to those of primary angioplasty. |
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Authors:
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J L Anderson |
Publication Detail:
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Type: Editorial |
Journal Detail:
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Title: The American journal of cardiology Volume: 80 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-01-20 Completed Date: 1998-01-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1588-90 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary Humans Myocardial Infarction / drug therapy* Myocardial Reperfusion Injury / etiology Thrombolytic Therapy* / adverse effects Treatment Failure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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