| Why does meconium cause meconium aspiration syndrome? Current concepts of MAS pathophysiology. | |
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MedLine Citation:
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PMID: 19833459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One in every 7 pregnancies ends with meconium-stained amniotic fluid and approximately 5% of these infants develop the meconium aspiration syndrome (MAS). MAS is a severe disease of the (mainly) term neonate, characterized by respiratory distress, pulmonary inflammation, persistent pulmonary hypertension and chronic hypoxia. The pathophysiology of MAS is multifactorial and complex. In this article, we discuss the mechanical and chemical effects of meconium on a newborn's airway, meconium-induced inflammation, mediated by proinflammatory cytokines and chemokines, the complement system and the proinflammatory enzyme phospholipase A2. Furthermore, we focus on MAS-related apoptotic cell death, causing severe acute lung injury due to damage and detachment of lung airway and alveolar cells. Finally, risk factors for MAS development to identify those newborns that develop MAS and those who do not are discussed. |
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Authors:
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Y van Ierland; A J de Beaufort |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Early human development Volume: 85 ISSN: 1872-6232 ISO Abbreviation: Early Hum. Dev. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-26 Completed Date: 2010-02-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 617-20 Citation Subset: IM |
Affiliation:
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Division of Neonatology, Juliana Children's Hospital, The Hague, The Netherlands. y.vanierland@erasmusmc.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis Chemokines / physiology Cytokines / physiology Humans Infant, Newborn Lung / embryology, pathology Meconium* Meconium Aspiration Syndrome / etiology*, pathology Phospholipases A2 / physiology Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Chemokines; 0/Cytokines; EC 3.1.1.4/Phospholipases A2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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