| Why does hydrosalpinx reduce fertility? The importance of hydrosalpinx fluid. | |
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MedLine Citation:
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PMID: 11980729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The debate on hydrosalpinx and impaired IVF outcome has mainly focused on the best treatment before IVF and on functional surgery as an alternative treatment. We would like to initiate a debate on the possible reasons why the outcome is impaired. We know that salpingectomy is effective in terms of improved birth rates after IVF, but we do not know exactly why. The main focus is on embryotoxic properties of the hydrosalpinx fluid, which include micro-organisms, endotoxins, cytokines, oxidative stress and lack of nutrients. The endometrial receptivity may be reduced as an effect of disturbed expression of the cytokine cascade, which is essential for implantation. The presence of excessive fluid in the uterine cavity may also be a mechanical hindrance to implantation. We believe that the hydrosalpinx fluid is of crucial importance, but the actual mechanism of action needs to be clarified. |
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Authors:
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Annika Strandell; Anette Lindhard |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 17 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-04-30 Completed Date: 2002-10-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 1141-5 Citation Subset: IM |
Affiliation:
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Reproductive Medicine, Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, S-413 45, Göteborg, Sweden. annika.strandell@medfak.gu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Embryo Transfer Embryo, Mammalian / physiology Fallopian Tube Diseases / complications*, physiopathology Female Fertilization in Vitro Follicular Fluid / physiology Humans Infertility, Female / etiology*, therapy |
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