Document Detail

Why do some T cell receptor cytoplasmic domains associate with the plasma membrane?
MedLine Citation:
PMID:  22566913     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Based on studies in model systems it has been proposed that the cytoplasmic domains of T cell receptor signaling subunits that have polybasic motifs associate with the plasma membrane, and that this regulates their phosphorylation. Recent experiments in more physiological systems have confirmed membrane association but raised questions as to its function.
P Anton van der Merwe; Hao Zhang; Shaun-Paul Cordoba
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Publication Detail:
Type:  Journal Article     Date:  2012-02-23
Journal Detail:
Title:  Frontiers in immunology     Volume:  3     ISSN:  1664-3224     ISO Abbreviation:  Front Immunol     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-08     Completed Date:  2012-08-23     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101560960     Medline TA:  Front Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  29     Citation Subset:  -    
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Grant Support
MR/J002011/1//Medical Research Council

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