| Why do red blood cells have asymmetric shapes even in a symmetric flow? | |
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MedLine Citation:
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PMID: 19905834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Understanding why red blood cells (RBCs) move with an asymmetric shape (slipperlike shape) in small blood vessels is a long-standing puzzle in blood circulatory research. By considering a vesicle (a model system for RBCs), we discovered that the slipper shape results from a loss in stability of the symmetric shape. It is shown that the adoption of a slipper shape causes a significant decrease in the velocity difference between the cell and the imposed flow, thus providing higher flow efficiency for RBCs. Higher membrane rigidity leads to a dramatic change in the slipper morphology, thus offering a potential diagnostic tool for cell pathologies. |
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Authors:
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Badr Kaoui; George Biros; Chaouqi Misbah |
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Publication Detail:
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Type: Letter; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-10-26 |
Journal Detail:
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Title: Physical review letters Volume: 103 ISSN: 1079-7114 ISO Abbreviation: Phys. Rev. Lett. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-11-12 Completed Date: 2010-02-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401141 Medline TA: Phys Rev Lett Country: United States |
Other Details:
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Languages: eng Pagination: 188101 Citation Subset: IM |
Affiliation:
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Laboratoire de Spectrom?trie Physique, UMR, 140 avenue de la physique, Universit? Joseph Fourier Grenoble, and CNRS, 38402 Saint Martin d'Heres, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biomechanics Blood Flow Velocity / physiology Blood Vessels / physiology Capillary Resistance Cell Membrane / chemistry, metabolism Cell Shape / physiology* Computer Simulation Elasticity Erythrocytes / cytology*, pathology, physiology* Hemoglobins / metabolism Models, Biological* Oxygen / metabolism Phospholipids / chemistry, metabolism Shear Strength Thermodynamics |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Phospholipids; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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