| Why do neurons die when deprived of trophic factor? | |
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MedLine Citation:
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PMID: 2812227 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this commentary we present circumstantial evidence which supports the hypothesis that neuronal death produced by trophic factor deprivation (i.e., axotomy, target loss, etc.) is not a passive process resulting from a loss of trophic stimulation. Rather, we suggest that it is due to the activation of an endogenous "suicide program" requiring mRNA and protein synthesis. The possible mechanistic relationship of neuronal death to death of other cell types, both in the developing and adult organism, is discussed. If this hypothesis of active death is true, then loss of transcriptional control of this program may be involved in neuronal attrition in aging or neurodegenerative disease. |
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Authors:
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E M Johnson; J Y Chang; T Koike; D P Martin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurobiology of aging Volume: 10 ISSN: 0197-4580 ISO Abbreviation: Neurobiol. Aging Publication Date: 1989 Sep-Oct |
Date Detail:
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Created Date: 1989-12-18 Completed Date: 1989-12-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 549-52; discussion 552-3 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Washington University Medical School, St. Louis, MO 63110. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Survival / drug effects Nerve Growth Factors / pharmacology, physiology* Nerve Tissue Proteins / metabolism*, physiology Nervous System / drug effects, metabolism Nervous System Physiological Phenomena* |
| Chemical | |
Reg. No./Substance:
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0/Nerve Growth Factors; 0/Nerve Tissue Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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