| Why do cells release vesicles? | |
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MedLine Citation:
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PMID: 20149923 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prokaryotic and eukaryotic cells release vesicles into their environment. To answer the question why eukaryotic cells release vesicles, we may learn from prokaryotes. Bacteria release outer membrane vesicles, resembling microparticles, which act as "multi-purpose carriers". They contain signalling molecules for other bacteria, deliver toxins to host cells and exchange DNA encoding virulence genes between bacteria. Similarly, cell-derived microparticles and exosomes from eukaryotic cells are multi-purpose carriers containing e.g. signalling molecules, cellular waste and functional genetic information. To illustrate our rapidly increasing knowledge on the multiple roles that cellular microparticles and exosomes play in disease progression, we focus on cancer, which is one of the best studied diseases in this aspect. The clinical applications of microparticles and exosomes, including diagnosis, prognosis and therapy, in cancer are discussed. |
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Authors:
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Rienk Nieuwland; Augueste Sturk |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-02-11 |
Journal Detail:
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Title: Thrombosis research Volume: 125 Suppl 1 ISSN: 1879-2472 ISO Abbreviation: Thromb. Res. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: United States |
Other Details:
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Languages: eng Pagination: S49-51 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Clinical Chemistry, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands. r.nieuwland@amc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigen-Presenting Cells
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metabolism Bacteria / metabolism* Cell-Derived Microparticles DNA / metabolism Dendritic Cells / metabolism Disease Progression Exosomes / metabolism* Humans Microspheres* Models, Genetic Neoplasms / metabolism* Signal Transduction Virulence |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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