Document Detail


Why do cells release vesicles?
MedLine Citation:
PMID:  20149923     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prokaryotic and eukaryotic cells release vesicles into their environment. To answer the question why eukaryotic cells release vesicles, we may learn from prokaryotes. Bacteria release outer membrane vesicles, resembling microparticles, which act as "multi-purpose carriers". They contain signalling molecules for other bacteria, deliver toxins to host cells and exchange DNA encoding virulence genes between bacteria. Similarly, cell-derived microparticles and exosomes from eukaryotic cells are multi-purpose carriers containing e.g. signalling molecules, cellular waste and functional genetic information. To illustrate our rapidly increasing knowledge on the multiple roles that cellular microparticles and exosomes play in disease progression, we focus on cancer, which is one of the best studied diseases in this aspect. The clinical applications of microparticles and exosomes, including diagnosis, prognosis and therapy, in cancer are discussed.
Authors:
Rienk Nieuwland; Augueste Sturk
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-02-11
Journal Detail:
Title:  Thrombosis research     Volume:  125 Suppl 1     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S49-51     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Clinical Chemistry, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands. r.nieuwland@amc.nl
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MeSH Terms
Descriptor/Qualifier:
Antigen-Presenting Cells / metabolism
Bacteria / metabolism*
Cell-Derived Microparticles
DNA / metabolism
Dendritic Cells / metabolism
Disease Progression
Exosomes / metabolism*
Humans
Microspheres*
Models, Genetic
Neoplasms / metabolism*
Signal Transduction
Virulence
Chemical
Reg. No./Substance:
9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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