| Why do cone photoreceptors die in rod-specific forms of retinal degenerations? | |
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MedLine Citation:
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PMID: 19941421 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Retinal degenerations such as retinitis pigmentosa (RP) lead to rod death due to apoptotic cell death, initiated by mutations in retinal genes that encode proteins with crucial photoreceptors functions. The mechanism(s) of cone death have remained elusive until this study. Using a combination of animal models of human RP, Affymetrix expression array studies, RT-PCR and immunohistochemical analyses, Punzo et al. determined that cone death is due to nutritional deficiencies, starration, and autophagy driven by the insulin/mTOR pathway. These novel and exciting seights also provide alternative avenues for therapeutic interventions for cone rescue. |
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Authors:
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Robert K Koenekoop |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Ophthalmic genetics Volume: 30 ISSN: 1744-5094 ISO Abbreviation: Ophthalmic Genet. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-11-27 Completed Date: 2010-02-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9436057 Medline TA: Ophthalmic Genet Country: England |
Other Details:
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Languages: eng Pagination: 152-4 Citation Subset: IM |
Affiliation:
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McGill Ocular Genetics Laboratory, McGill University Health Center, Montreal, Quebec, Canada. robert.koenekoop@mcgill.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* Autophagy Humans Retinal Cone Photoreceptor Cells / pathology* Retinal Rod Photoreceptor Cells / pathology* Retinitis Pigmentosa / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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