Document Detail

Why do B cells produce CD40 ligand?
MedLine Citation:
PMID:  12848855     Owner:  NLM     Status:  MEDLINE    
The CD40-CD40 ligand (CD40L) interaction is one of the most important receptor-ligand interactions that occurs during a T dependent immune response. However, while CD40L is expressed on a range of cell types including activated T cells and B cells, dendritic cells granulocytes, macrophages and platelets, only CD40L on T cells is considered by most immunologists when planning experiments or analysing data. The current theory professes that T cells expressing CD40L can provide signals to B cells that induce proliferation, immunoglobulin class switching, antibody secretion, rescue from apoptosis at different times during the life of a B cell and also has a role in the development of germinal centres and the survival of memory B cells. However, the whole story is more complex than presently understood as human and mouse B cells express CD40L on their surface following activation and can release a soluble form of the ligand. This paper hypothesizes how CD40L on B cells may regulate antibody responses and the development of germinal centres.
Michelle Wykes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunology and cell biology     Volume:  81     ISSN:  0818-9641     ISO Abbreviation:  Immunol. Cell Biol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-09     Completed Date:  2004-03-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8706300     Medline TA:  Immunol Cell Biol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  328-31     Citation Subset:  IM    
Queensland Institute of Medical Research, The Bancroft Centre, Herston Road, Brisbane 4006, Australia.
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MeSH Terms
Antigens, CD40 / immunology*,  metabolism
B-Lymphocytes / immunology*,  metabolism
CD40 Ligand / metabolism,  physiology*
Cell Membrane / immunology,  metabolism
Lymphocyte Activation
Models, Immunological
Reg. No./Substance:
0/Antigens, CD40; 147205-72-9/CD40 Ligand

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