Document Detail

Why avoid the hippocampus? A comprehensive review.
MedLine Citation:
PMID:  20970214     Owner:  NLM     Status:  MEDLINE    
In this review article, we provide a detailed and comprehensive discussion of the rationale for using modern IMRT techniques to spare the subgranular zone of the hippocampus during cranial irradiation. We review the literature on neurocognitive effects of cranial irradiation; discuss clinical and preclinical data associating damage to neural progrenitor cells located in subgranular zone of the hippocampus with radiation-induced neurocognitive decline, specifically in terms of short-term memory formation and recall; and present a review of our pilot investigations into the feasibility and risks of sparing the subgranular zone of the hippocampus during whole-brain radiotherapy for brain metastases. We also introduce our phase II cooperative group clinical trial (RTOG 0933) designed to prospectively evaluate the postulated neurocognitive benefit of hippocampal subgranular zone sparing and scheduled to open in 2010.
Vinai Gondi; Wolfgang A Tomé; Minesh P Mehta
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-10-20
Journal Detail:
Title:  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology     Volume:  97     ISSN:  1879-0887     ISO Abbreviation:  Radiother Oncol     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-29     Completed Date:  2011-03-22     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8407192     Medline TA:  Radiother Oncol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  370-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA.
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MeSH Terms
Brain Neoplasms / pathology,  radiotherapy,  secondary
Cognition Disorders / etiology*
Cranial Irradiation / adverse effects*,  methods
Disease Progression
Executive Function / radiation effects
Hippocampus / radiation effects*
Memory / radiation effects*
Psychomotor Performance / radiation effects
Radiotherapy Dosage
Word Association Tests
Grant Support
R01 CA109656-01A1/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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