| Why avoid the hippocampus? A comprehensive review. | |
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MedLine Citation:
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PMID: 20970214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this review article, we provide a detailed and comprehensive discussion of the rationale for using modern IMRT techniques to spare the subgranular zone of the hippocampus during cranial irradiation. We review the literature on neurocognitive effects of cranial irradiation; discuss clinical and preclinical data associating damage to neural progrenitor cells located in subgranular zone of the hippocampus with radiation-induced neurocognitive decline, specifically in terms of short-term memory formation and recall; and present a review of our pilot investigations into the feasibility and risks of sparing the subgranular zone of the hippocampus during whole-brain radiotherapy for brain metastases. We also introduce our phase II cooperative group clinical trial (RTOG 0933) designed to prospectively evaluate the postulated neurocognitive benefit of hippocampal subgranular zone sparing and scheduled to open in 2010. |
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Authors:
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Vinai Gondi; Wolfgang A Tomé; Minesh P Mehta |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-10-20 |
Journal Detail:
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Title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Volume: 97 ISSN: 1879-0887 ISO Abbreviation: Radiother Oncol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-29 Completed Date: 2011-03-22 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 8407192 Medline TA: Radiother Oncol Country: Ireland |
Other Details:
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Languages: eng Pagination: 370-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA. gondi@humonc.wisc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain Neoplasms
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pathology,
radiotherapy,
secondary Cognition Disorders / etiology* Cranial Irradiation / adverse effects*, methods Disease Progression Executive Function / radiation effects Hippocampus / radiation effects* Humans Memory / radiation effects* Psychomotor Performance / radiation effects Radiotherapy Dosage Word Association Tests |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA109656-01A1/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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