Document Detail


Why are sperm cells phagocytosed by leukocytes in the female genital tract?
MedLine Citation:
PMID:  12615529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When mammalian sperm cells enter the female genital tract, many of them are attacked and phagocytosed by leukocytes and epithelial cells. Although this intriguing phenomenon is known for almost five decades, there is no satisfactory explanation for it. Here, on the basis of recent information on the nature of the capacitated stage of mammalian sperm cells, that is, the sperm's stage of readiness for fertilizing the egg, I put forward the hypothesis that the phagocytosed sperm cells are post-capacitated cells. These cells, which lost their fertilizing ability and became functionless, apparently recruit leukocytes and then undergo apoptosis and phagocytosis and, thereby, are removed from the female genital tract. This fast removal probably prevents severe inflammation that could have been caused by necrotic products of sperm cells that remain functionless in the tract.
Authors:
Michael Eisenbach
Related Documents :
7785059 - Peroxisome proliferator-activated receptor response specificities as defined in yeast a...
945269 - Folate metabolism in mammalian cells in culture. i partial characterization of the fola...
22574079 - Cytological diagnosis of metastatic alveolar rhabdomyosarcoma in the ascitic fluid: rep...
25271129 - Biophysical profiling of tumor cell lines.
15013789 - Plasmodium falciparum: selenium-induced cytotoxicity to p. falciparum.
8985329 - Varicella-zoster virus fc receptor ge glycoprotein: serine/threonine and tyrosine phosp...
24173519 - In vivo diversification and migrations of chick embryo heart muscle cells: a morphometr...
16786109 - Cigarette smoke extract inhibits the proliferation of alveolar epithelial cells and ind...
9839709 - The effects of oestrogen on osteocalcin production by human periodontal ligament cells.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  60     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-04     Completed Date:  2003-12-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  590-2     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Elsevier Science Ltd.
Affiliation:
The Weizmann Institute of Science, Rehovot, Israel. m.eisenbach@weizmann.ac.il
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Female
Humans
Leukocytes / metabolism*
Male
Models, Biological
Necrosis
Phagocytosis*
Spermatozoa / metabolism*
Urogenital System / metabolism

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The metabolic syndrome as a vicious cycle: does obesity beget obesity?
Next Document:  Is ATP-sensitive K+ channel (K+ATP) recruitment a common mechanism for ECG-ST segment depression and...