Document Detail

Why all the confusion? Experimental task explains discrepant semantic priming effects in schizophrenia under "automatic" conditions: evidence from Event-Related Potentials.
MedLine Citation:
PMID:  19386472     Owner:  NLM     Status:  MEDLINE    
The schizophrenia research literature contains many differing accounts of semantic memory function in schizophrenia as assessed through the semantic priming paradigm. Most recently, Event-Related Potentials (ERPs) have been used to demonstrate both increased and decreased semantic priming at a neural level in schizophrenia patients, relative to healthy controls. The present study used ERPs to investigate the role of behavioral task in determining neural semantic priming effects in schizophrenia. The same schizophrenia patients and healthy controls completed two experiments in which word stimuli were identical, and the time between the onset of prime and target remained constant at 350 ms: in the first, participants monitored for words within a particular semantic category that appeared only in filler items (implicit task); in the second, participants explicitly rated the relatedness of word-pairs (explicit task). In the explicit task, schizophrenia patients showed reduced direct and indirect semantic priming in comparison with healthy controls. In contrast, in the implicit task, schizophrenia patients showed normal or, in positively thought-disordered patients, increased direct and indirect N400 priming effects compared with healthy controls. These data confirm that, although schizophrenia patients with positive thought disorder may show an abnormally increased automatic spreading activation, the introduction of semantic decision-making can result in abnormally reduced semantic priming in schizophrenia, even when other experimental conditions bias toward automatic processing.
Donna A Kreher; Donald Goff; Gina R Kuperberg
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-04-21
Journal Detail:
Title:  Schizophrenia research     Volume:  111     ISSN:  1573-2509     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-08-25     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  174-81     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Association Learning / physiology
Brain Mapping
Electroencephalography / methods
Evoked Potentials / physiology*
Middle Aged
Neuropsychological Tests
Photic Stimulation / methods
Reaction Time
Schizophrenia / physiopathology*
Schizophrenic Psychology*
Time Factors
Grant Support
R01 HD025889-12/HD/NICHD NIH HHS; R01 HD043251/HD/NICHD NIH HHS; R01 HD043251-03/HD/NICHD NIH HHS; R01 HD25889/HD/NICHD NIH HHS; R01 MH071635/MH/NIMH NIH HHS; R01 MH071635-04/MH/NIMH NIH HHS; R37 HD025889/HD/NICHD NIH HHS

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