| Why all the confusion? Experimental task explains discrepant semantic priming effects in schizophrenia under "automatic" conditions: evidence from Event-Related Potentials. | |
| | |
MedLine Citation:
|
PMID: 19386472 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The schizophrenia research literature contains many differing accounts of semantic memory function in schizophrenia as assessed through the semantic priming paradigm. Most recently, Event-Related Potentials (ERPs) have been used to demonstrate both increased and decreased semantic priming at a neural level in schizophrenia patients, relative to healthy controls. The present study used ERPs to investigate the role of behavioral task in determining neural semantic priming effects in schizophrenia. The same schizophrenia patients and healthy controls completed two experiments in which word stimuli were identical, and the time between the onset of prime and target remained constant at 350 ms: in the first, participants monitored for words within a particular semantic category that appeared only in filler items (implicit task); in the second, participants explicitly rated the relatedness of word-pairs (explicit task). In the explicit task, schizophrenia patients showed reduced direct and indirect semantic priming in comparison with healthy controls. In contrast, in the implicit task, schizophrenia patients showed normal or, in positively thought-disordered patients, increased direct and indirect N400 priming effects compared with healthy controls. These data confirm that, although schizophrenia patients with positive thought disorder may show an abnormally increased automatic spreading activation, the introduction of semantic decision-making can result in abnormally reduced semantic priming in schizophrenia, even when other experimental conditions bias toward automatic processing. |
| | |
Authors:
|
Donna A Kreher; Donald Goff; Gina R Kuperberg |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-04-21 |
Journal Detail:
|
Title: Schizophrenia research Volume: 111 ISSN: 1573-2509 ISO Abbreviation: Schizophr. Res. Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-05-11 Completed Date: 2009-08-25 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 174-81 Citation Subset: IM |
Affiliation:
|
Department of Psychology, Tufts University, 490 Boston Ave, Medford, MA 02155, USA. dkreher@psych.umass.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Analysis of Variance Association Learning / physiology Brain Mapping Electroencephalography / methods Evoked Potentials / physiology* Female Humans Male Middle Aged Neuropsychological Tests Photic Stimulation / methods Reaction Time Schizophrenia / physiopathology* Schizophrenic Psychology* Semantics* Time Factors Vocabulary |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HD025889-12/HD/NICHD NIH HHS; R01 HD043251/HD/NICHD NIH HHS; R01 HD043251-03/HD/NICHD NIH HHS; R01 HD25889/HD/NICHD NIH HHS; R01 MH071635/MH/NIMH NIH HHS; R01 MH071635-04/MH/NIMH NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intraosseous lipoma of the mandible: a case report and review of the literature.
Next Document: An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of sc...