Document Detail

Why is DNA damage signaling so complicated? Chaos and molecular signaling.
MedLine Citation:
PMID:  11746746     Owner:  NLM     Status:  MEDLINE    
Molecular signaling in eukaryotic cells is accomplished by complex and redundant pathways converging on key molecules that are allosterically controlled by a limited number of signaling proteins. The p53-signaling pathway is an example of a complicated sequence of signals produced in response to DNA damage. This pattern of signaling may arise from chance occurrences at the origin of life and the necessities imposed on a nanomolar system. From this viewpoint, chaos theory may explain the origin, complexity, and convergence of these pathways.
D B Yarosh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental and molecular mutagenesis     Volume:  38     ISSN:  0893-6692     ISO Abbreviation:  Environ. Mol. Mutagen.     Publication Date:  2001  
Date Detail:
Created Date:  2001-12-17     Completed Date:  2002-01-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8800109     Medline TA:  Environ Mol Mutagen     Country:  United States    
Other Details:
Languages:  eng     Pagination:  132-4     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Wiley-Liss, Inc.
AGI Dermatics, Freeport, New York 11520, USA.
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MeSH Terms
DNA Damage*
DNA Repair*
Genes, p53
Nonlinear Dynamics
Signal Transduction

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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