| Who's in charge here? Regulating cell cycle regulators. | |
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MedLine Citation:
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PMID: 18955157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies have illuminated key features of the transcriptional and signal transduction networks governing the cell division cycle of Caulobacter crescentus. These mechanisms generate oscillations in the activity of CtrA, a key regulator of DNA replication and transcription of cell cycle regulated genes. ctrA transcription is itself regulated as part of a cascade of transcriptional regulators, each of which drives the synthesis of proteins needed at different stages of the cell cycle. The CtrA protein is post-transcriptionally regulated by an extended network of two-component signaling proteins and by proteolysis. Proteins within these pathways are localized at opposite ends of the cell to generate two progenies in different stages of the cell cycle upon cell division. |
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Authors:
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Lisa M Bowers; Elaine B Shapland; Kathleen R Ryan |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-11-03 |
Journal Detail:
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Title: Current opinion in microbiology Volume: 11 ISSN: 1879-0364 ISO Abbreviation: Curr. Opin. Microbiol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-02 Completed Date: 2009-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815056 Medline TA: Curr Opin Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 547-52 Citation Subset: IM |
Affiliation:
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Department of Plant & Microbial Biology, 251 Koshland Hall, University of California, Berkeley, Berkeley, CA 94720, USA. lbowers@nature.berkeley.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Proteins
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metabolism Caulobacter crescentus / growth & development, physiology* Cell Cycle* DNA Replication* DNA-Binding Proteins / metabolism Gene Expression Regulation, Bacterial* Signal Transduction Transcription Factors / metabolism Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/CtrA protein, Caulobacter; 0/DNA-Binding Proteins; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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