Document Detail


Whole and particle-free diesel exhausts differentially affect cardiac electrophysiology, blood pressure, and autonomic balance in heart failure-prone rats.
MedLine Citation:
PMID:  22543275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidemiological studies strongly link short-term exposures to vehicular traffic and particulate matter (PM) air pollution with adverse cardiovascular (CV) events, especially in those with preexisting CV disease. Diesel engine exhaust is a key contributor to urban ambient PM and gaseous pollutants. To determine the role of gaseous and particulate components in diesel exhaust (DE) cardiotoxicity, we examined the effects of a 4-h inhalation of whole DE (wDE) (target PM concentration: 500 µg/m(3)) or particle-free filtered DE (fDE) on CV physiology and a range of markers of cardiopulmonary injury in hypertensive heart failure-prone rats. Arterial blood pressure (BP), electrocardiography, and heart rate variability (HRV), an index of autonomic balance, were monitored. Both fDE and wDE decreased BP and prolonged PR interval during exposure, with more effects from fDE, which additionally increased HRV triangular index and decreased T-wave amplitude. fDE increased QTc interval immediately after exposure, increased atrioventricular (AV) block Mobitz II arrhythmias shortly thereafter, and increased serum high-density lipoprotein 1 day later. wDE increased BP and decreased HRV root mean square of successive differences immediately postexposure. fDE and wDE decreased heart rate during the 4th hour of postexposure. Thus, DE gases slowed AV conduction and ventricular repolarization, decreased BP, increased HRV, and subsequently provoked arrhythmias, collectively suggesting parasympathetic activation; conversely, brief BP and HRV changes after exposure to particle-containing DE indicated a transient sympathetic excitation. Our findings suggest that whole- and particle-free DE differentially alter CV and autonomic physiology and may potentially increase risk through divergent pathways.
Authors:
Alex P Carll; Mehdi S Hazari; Christina M Perez; Quentin Todd Krantz; Charly J King; Darrell W Winsett; Daniel L Costa; Aimen K Farraj
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-26
Journal Detail:
Title:  Toxicological sciences : an official journal of the Society of Toxicology     Volume:  128     ISSN:  1096-0929     ISO Abbreviation:  Toxicol. Sci.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-16     Completed Date:  2013-01-25     Revised Date:  2014-03-28    
Medline Journal Info:
Nlm Unique ID:  9805461     Medline TA:  Toxicol Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  490-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autonomic Nervous System / drug effects*
Blood Pressure / drug effects*
Heart / drug effects*
Heart Failure / physiopathology
Inhalation Exposure
Male
Particle Size
Rats
Vehicle Emissions / toxicity*
Grant Support
ID/Acronym/Agency:
T32 ES007126/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Vehicle Emissions
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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