| Whole pancreatic blood flow and islet blood flow in hypovolemic hypotension in rats. | |
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MedLine Citation:
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PMID: 1425826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The blood volume of adult, male rats was reduced with 5 ml (approximately 30% of the total blood volume) by bleeding, which reduced the mean arterial blood pressure (MAP) to 50 mm Hg. This hemorrhagic hypotension caused an increase in both serum glucose and serum insulin concentrations when compared with either normotensive control animals or with rats infused with nitroprusside to obtain an MAP similar to that of the bled animals. The blood perfusion of the whole pancreas was reduced in both groups of hypotensive animals but more markedly in those with hemorrhagic hypotension. The islet blood flow was reduced only in the bled animals. The percentage fraction of blood diverted through the islet organ was markedly increased in bled rats compared to the control animals, whilst this increase was less pronounced in the nitroprusside-infused rats. The vascular conductance in the nitroprusside-treated rats was unchanged for the whole gland, but increased for the islets. Both these values in bled animals were decreased. It is concluded that the blood flow regulation differs between the endocrine and exocrine parts of the pancreas in hypovolemic hypotension. |
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Authors:
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L Jansson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes Volume: 24 ISSN: 0014-312X ISO Abbreviation: Eur Surg Res Publication Date: 1992 |
Date Detail:
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Created Date: 1992-12-22 Completed Date: 1992-12-22 Revised Date: 2006-11-30 |
Medline Journal Info:
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Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 291-7 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Uppsala University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / analysis Blood Volume* Hypotension / etiology, physiopathology* Insulin / blood Islets of Langerhans / blood supply* Male Nitroprusside Pancreas / blood supply* Rats Rats, Sprague-Dawley Regional Blood Flow |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin; 15078-28-1/Nitroprusside |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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