Document Detail


Whole-grain rye and wheat foods and markers of bowel health in overweight middle-aged men.
MedLine Citation:
PMID:  12663299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Whole-grain cereal foods including rye have been identified as providing significant health benefits that do not occur when refined-cereal foods are ingested. OBJECTIVES: Foods (90 g) containing whole-grain rye flour and whole-grain wheat flour were compared with low-fiber refined-cereal foods for their effects on markers of bowel health and the metabolic markers insulin and glucose. DESIGN: Three 4-wk interventions were undertaken in a randomized crossover design with 28 overweight men aged 40-65 y who had no history of bowel disease. Against a background intake of 14 g dietary fiber (DF), the men were fed low-fiber cereal grain foods providing 5 g DF for a total of 19 g DF/d. High-fiber wheat foods provided 18 g DF, and high-fiber rye foods provided 18 g DF, both giving a total of 32 g DF/d. Fecal samples (48-h) and fasting and postprandial blood samples were collected at the end of each period and assayed. RESULTS: Both high-fiber rye and wheat foods increased fecal output by 33-36% (P = 0.004) and reduced fecal beta-glucuronidase activity by 29% (P = 0.027). Postprandial plasma insulin was decreased by 46-49% (P = 0.0001) and postprandial plasma glucose by 16-19% (P = 0.0005). Rye foods were associated with significantly (P = 0.0001) increased plasma enterolactone (47% and 71%) and fecal butyrate (26% and 36%), relative to wheat and low-fiber options, respectively. CONCLUSIONS: High-fiber rye and wheat food consumption improved several markers of bowel and metabolic health relative to that of low-fiber food. Fiber from rye appears more effective than that from wheat in overall improvement of biomarkers of bowel health.
Authors:
Graeme H McIntosh; Manny Noakes; Peter J Royle; Paul R Foster
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  77     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-28     Completed Date:  2003-04-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  967-74     Citation Subset:  AIM; IM    
Affiliation:
Commonwealth Scientific & Industrial Research Organisation Health Sciences and Nutrition, Adelaide, Australia. graeme.mcintosh@csiro.au
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MeSH Terms
Descriptor/Qualifier:
4-Butyrolactone / analogs & derivatives*,  blood
Ammonia / analysis
Biological Markers / analysis*
Blood Glucose / analysis
Butyrates / analysis
Cresols / analysis,  blood
Cross-Over Studies
Defecation
Diet
Dietary Fiber / administration & dosage*
Feces / chemistry
Food
Glucuronidase / analysis
Humans
Hydrogen-Ion Concentration
Insulin / blood
Intestines / physiology*
Lignans / blood
Male
Middle Aged
Propionic Acids / analysis
Secale cereale*
Triticum*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Butyrates; 0/Cresols; 0/Lignans; 0/Propionic Acids; 106-44-5/4-cresol; 11061-68-0/Insulin; 76543-15-2/2,3-bis(3'-hydroxybenzyl)butyrolactone; 7664-41-7/Ammonia; 79-09-4/propionic acid; 96-48-0/4-Butyrolactone; EC 3.2.1.31/Glucuronidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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