| Whole globe enucleation versus in situ excision for donor corneal retrieval--a prospective comparative study. | |
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MedLine Citation:
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PMID: 19034121 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The purpose of this study was to compare the results after changing from conventional whole globe enucleation to in situ excision of donor corneas. METHODS: Donor corneal tissue retrieved by enucleation (n = 50) and in situ excision (n = 50) was quantitatively evaluated prospectively, and the main parameters evaluated were endothelial cell counts, ultrasonic corneal pachymetry, microbial contamination, graft clarity, and postoperative median visual acuity at the end of 3 months. RESULTS: Mean preoperative donor endothelial cell densities were 2174 +/- 123 and 2132 +/- 149 cells per millimeter square after enucleation and in situ excision, respectively (P = 0.13). The preoperative disease distribution and visual potential of recipients were comparable between the 2 groups. Corneal pachymetry was lower in the whole globe group at the end of 3 months (528 microm, enucleation group; and 539 microm, in situ group; P = 0.01). The mean postoperative endothelial cell counts were comparable in both groups at 3 months (1708 +/- 104.8/mm for whole globe group, measured in 40 eyes, vs 1674 +/- 117.4/mm in in situ group, recorded in 39 eyes; P = 0.18). The number of positive corneoscleral rim cultures postkeratoplasty was statistically comparable in both groups (20% in enucleation group and 24% in in situ group; P = 0.62). At 3 months, 98% and 92% of grafts had a graft clarity of >or=3+ in whole globe and in situ groups, respectively (P = 0.16). Seventy-two percent of patients in whole globe group and 67% in in situ group achieved a best-corrected visual acuity of >or=0.1. Postoperative graft infection developed in 2 cases in the in situ group. CONCLUSIONS: Changeover from whole globe enucleation technique to in situ excision technique of harvesting donor corneas demonstrated that in situ excision is a viable alternative. |
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Authors:
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Vishal Jhanji; Radhika Tandon; Namrata Sharma; Jeewan S Titiyal; Gita Satpathy; Rasik B Vajpayee |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Cornea Volume: 27 ISSN: 1536-4798 ISO Abbreviation: Cornea Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-26 Completed Date: 2009-02-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8216186 Medline TA: Cornea Country: United States |
Other Details:
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Languages: eng Pagination: 1103-8 Citation Subset: IM |
Affiliation:
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Cornea and Refractive Surgery Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Bacteria / isolation & purification Cell Count Cornea / microbiology, pathology, surgery* Corneal Transplantation / adverse effects Corneal Ulcer / etiology Endophthalmitis / etiology Endothelium, Corneal / pathology Eye Enucleation* Fungi / isolation & purification Humans Infection / etiology Middle Aged Postoperative Period Prospective Studies Tissue Donors Tissue and Organ Harvesting / methods* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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