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Whole and fractionated yellow pea flours modulate insulin, glucose, oxygen consumption, and the caecal microbiome in Golden Syrian hamsters.
MedLine Citation:
PMID:  22026418     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The objective was to evaluate the effects of whole and fractionated yellow peas on circulating lipids, glucose and insulin levels, energy expenditure, and body composition, as well as to assess their prebiotic actions in Golden Syrian hamsters. Forty-five hamsters consumed a hypercholesterolemic diet for 28 days, then were randomly assigned to 1 of 3 groups: control (CON), whole pea flour (WPF), and fractionated pea flour (hulls only) (FPF). WPF and FPF were incorporated into the diets, replacing 10% of the cornstarch. WPF and FPF feeding produced negligible effects on circulating cholesterol and triglyceride levels. However, both WPF (56.76 ± 9.22 pmol·L(-1), p = 0.002) and FPF (89.27 ± 19.82 pmol·L(-1), p = 0.032) reduced circulating insulin levels compared with the CON group (131.70 ± 17.70 pmol·L(-1)). Moreover, FPF decreased (p = 0.03) circulating glucose levels (6.26 ± 0.51 mmol·L(-1)) compared with CON (8.27 ± 0.81 mmol·L(-1)). Energy expenditure analysis revealed that hamsters consuming WPF demonstrated a higher (p = 0.036) oxygen consumption (2.00 ± 0.31 mL O(2)·g(-1) lean body mass) vs. the CON group (1.56 ± 0.089 mL O(2)·g(-1) lean body mass). Analysis of caecal digesta showed that WPF produced shifts in the abundance of microbial taxa with the most predominant changes occurring within the phylum Firmicutes. Yellow peas and their constituents should be investigated as future functional food ingredients that help prevent and manage lifestyle-related diseases such as diabetes and obesity.
Authors:
Christopher P F Marinangeli; Denis Krause; Scott V Harding; Todd C Rideout; Fuqin Zhu; Peter J H Jones
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-25
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme     Volume:  -     ISSN:  1715-5312     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a University of Manitoba, Richardson Centre for Functional Foods and Nutraceuticals, 196 Innovation Drive, Winnipeg, MB R3T 2N2, Canada.
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