Document Detail

Whole-food sources of vitamin A more effectively inhibit female rat sexual maturation, mammary gland development, and mammary carcinogenesis than retinyl palmitate.
MedLine Citation:
PMID:  17513400     Owner:  NLM     Status:  MEDLINE    
Previous work using an adolescent rat model for breast cancer showed increased tumor occurrence in rats fed a chemopreventive dose of vitamin A. Preclinical models for nutrient-cancer interactions utilizing defined diets do not replicate the complexity of the human diet and may be inadequate to investigate food patterns associated with reduced cancer risk in humans. To evaluate this concept, the effects of vitamin A on sexual maturation, mammary gland development, and sensitivity to carcinogenesis were determined in the context of a human food-based diet (whole food diet). At 20 d of age (p20), female rats received either a whole-food diet with adequate levels of vitamin A, a diet with a 5.5-fold increase in vitamin A from fruits and vegetables (S diet), or a diet with a 6.2-fold increase in vitamin A provided as retinyl palmitate (RP diet). To determine the effect of dietary intervention on pubertal mammary gland development, the dietary intervention period was restricted to postnatal d 21-63. Rats were injected with 50 mg 1-methyl-1-nitrosourea/kg body weight at d 66. Compared with adolescent rats that consumed the Ad diet, consumption of S and RP diets reduced mammary cancer multiplicity (relative risk approximately 0.7, P < or = 0.002), which was associated with a reduction in alveolar gland development. The S diet suppressed the onset of sexual maturation (P < 0.001) and inhibited markers of mammary alveologenesis more than the RP diet. These data demonstrate that the amount and source of vitamin A consumed by adolescent female rats can influence the onset of puberty, mammary gland alveolar development, and breast cancer risk and highlight the relevance of utilizing whole-food diets to evaluate the role of dietary factors in cancer prevention.
Shauntae M McDaniel; Caitlin O'Neill; Richard P Metz; Elizabeth Tarbutton; Maria Stacewicz-Sapuntzakis; Jerianne Heimendinger; Pamela Wolfe; Henry Thompson; Pepper Schedin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  137     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-21     Completed Date:  2007-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1415-22     Citation Subset:  IM    
Department of Medicine, Division of Medical Oncology and Colorado Cancer Center, University of Colorado Health Science Center, Aurora, CO 80010, USA.
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MeSH Terms
Anticarcinogenic Agents / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Mammary Glands, Animal / growth & development*
Mammary Neoplasms, Animal / prevention & control*
Rats, Sprague-Dawley
Sexual Development / drug effects*
Vitamin A / administration & dosage,  analogs & derivatives*,  blood,  pharmacology*
Reg. No./Substance:
0/Anticarcinogenic Agents; 11103-57-4/Vitamin A; 79-81-2/retinol palmitate

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