Document Detail


Whole chromosome 17 loss in ovarian cancer.
MedLine Citation:
PMID:  7509629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chromosomal deletions, associated with the loss of normal function of tumour suppressor genes, have been identified in a variety of both familial and sporadic human cancers. Although the molecular pathology of ovarian cancer is not understood, several studies have reported deletions in chromosome 17 in ovarian tumours. We have used 13 restriction site polymorphic, microsatellite, and variable number tandem repeat markers to make a detailed analysis of chromosome 17 deletions in 12 benign and 19 malignant ovarian tumours. Two benign and 11 malignant tumours were informative for at least one marker on each arm of the chromosome. Loss of heterozygosity (LOH) was detected in both arms (by all informative markers) in 5 malignant tumours from four women (three with the disease at FIGO stage Ia). In a further bilateral ovarian tumour a partial LOH affecting 17q22-q25 was present in one ovary only. By contrast to a number of previous studies, none of the 19 malignant and 12 benign tumours showed ERBB2 (17q12-22) amplification. The data presented show that the loss of a whole copy of chromosome 17 is a frequent and relatively early event in the development of some ovarian cancers. This suggests the possible involvement of multiple chromosome 17 loci in the pathogenesis of ovarian cancer. Equally plausible is that the loss of a whole chromosome copy could be the product of chromosomal instabilities induced by loss of the normal allele of tumour suppressors, such as TP53, located on this chromosome.
Authors:
M Tavassoli; C Ruhrberg; V Beaumont; K Reynolds; N Kirkham; W P Collins; F Farzaneh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  8     ISSN:  1045-2257     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-04-07     Completed Date:  1994-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  195-8     Citation Subset:  IM    
Affiliation:
School of Biological Sciences, University of Sussex, Brighton, UK.
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MeSH Terms
Descriptor/Qualifier:
Adenofibroma / genetics*
Blotting, Southern
Carcinoma / genetics*
Chromosome Mapping
Chromosomes, Human, Pair 17*
Cystadenoma, Serous / genetics*
DNA, Neoplasm / analysis
Female
Heterozygote
Humans
Monosomy / genetics*
Ovarian Neoplasms / genetics*
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Tumor Markers, Biological
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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