Document Detail

Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS.
MedLine Citation:
PMID:  23325907     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To demonstrate the sensitivity of a recently developed whole-brain magnetic resonance spectroscopic imaging (MRSI) sequence to cerebral pathology and disability in amyotrophic lateral sclerosis (ALS), and compare with measures derived from diffusion tensor imaging.
METHODS: Whole-brain MRSI and diffusion tensor imaging were undertaken in 13 patients and 14 age-similar healthy controls. Mean N-acetylaspartate (NAA), fractional anisotropy, and mean diffusivity were extracted from the corticospinal tract, compared between groups, and then in relation to disability in the patient group.
RESULTS: Significant reductions in NAA were found along the course of the corticospinal tracts on whole-brain MRSI. There were also significant changes in fractional anisotropy (decreased) and mean diffusivity (increased) in the patient group, but only NAA showed a significant relationship with disability (r = 0.65, p = 0.01).
CONCLUSION: Whole-brain MRSI has potential as a quantifiable neuroimaging marker of disability in ALS. It offers renewed hope for a neuroimaging outcome measure with the potential for harmonization across multiple sites in the context of a therapeutic trial.
Charlotte J Stagg; Steven Knight; Kevin Talbot; Mark Jenkinson; Andrew A Maudsley; Martin R Turner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-16
Journal Detail:
Title:  Neurology     Volume:  80     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-12     Completed Date:  2013-04-08     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  610-5     Citation Subset:  AIM; IM    
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MeSH Terms
Amyotrophic Lateral Sclerosis / pathology*,  physiopathology*
Aspartic Acid / analogs & derivatives,  metabolism
Brain / metabolism*
Case-Control Studies
Creatine / metabolism
Diffusion Magnetic Resonance Imaging / methods
Disability Evaluation
Disabled Persons*
Magnetic Resonance Spectroscopy*
Middle Aged
Grant Support
BB/C519938/1//Biotechnology and Biological Sciences Research Council; G0701923//Medical Research Council; R01EB000822/EB/NIBIB NIH HHS; //Department of Health; //Medical Research Council
Reg. No./Substance:
30KYC7MIAI/Aspartic Acid; 997-55-7/N-acetylaspartate; MU72812GK0/Creatine
Comment In:
Nat Rev Neurol. 2013 Mar;9(3):120   [PMID:  23381477 ]
Neurology. 2013 Feb 12;80(7):606-7   [PMID:  23325912 ]

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