Document Detail


Whole brain and localized magnetization transfer measurements are associated with cognitive impairment in patients infected with human immunodeficiency virus.
MedLine Citation:
PMID:  17928382     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Patients infected with human immunodeficiency virus (HIV) are susceptible to cognitive deterioration. This study investigated the utility of magnetization transfer (MT) imaging for quantification of brain tissue alterations associated with cognitive deficits in patients with HIV.
MATERIALS AND METHODS: MT ratios (MTR) were derived for whole brain and for regions of interest (ROIs) in the basal ganglia and white matter in 11 HIV and 12 control subjects. Relationships with severity of cognitive impairment and specific neuropsychological deficits were also evaluated.
RESULTS: MTR values for normalized whole brain histogram peak height, whole brain histogram mean, and all examined ROIs were reduced in the HIV subjects. Normalized histogram peak height and mean for whole brain, as well as means for the corpus callosum, basal ganglia, and frontal white matter (FWM), were significantly correlated with severity of cognitive impairment. MTR values for white matter regions (corpus callosum, FWM, and centrum semiovale) were correlated with specific cognitive deficits.
CONCLUSION: Quantitative MTR measurements, determined for the whole brain and for vulnerable ROIs, are sensitive to neuropathologic changes associated with cognitive impairment in HIV-infected patients.
Authors:
Y Wu; P Storey; A Carrillo; C Saglamer; B A Cohen; L G Epstein; R R Edelman; A B Ragin
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural     Date:  2007-10-10
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  29     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-04-28     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  140-5     Citation Subset:  IM    
Affiliation:
Department of Radiology, Evanston Northwestern Healthcare, Evanston, Ill, USA. wu7@northwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Brain / pathology*
Cognition Disorders / diagnosis*
Encephalitis, Viral / diagnosis*
Female
HIV Infections / diagnosis*
Humans
Image Interpretation, Computer-Assisted / methods*
Magnetic Resonance Imaging / methods*
Magnetics / diagnostic use*
Male
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Statistics as Topic
Grant Support
ID/Acronym/Agency:
K23 MH066705/MH/NIMH NIH HHS; K23 MH066705-01/MH/NIMH NIH HHS; K23 MH066705-02/MH/NIMH NIH HHS; K23 MH066705-02S1/MH/NIMH NIH HHS; K23 MH066705-03/MH/NIMH NIH HHS; K23 MH066705-04/MH/NIMH NIH HHS; K23 MH066705-05/MH/NIMH NIH HHS; K23 MH66705/MH/NIMH NIH HHS; MH63039/MH/NIMH NIH HHS; MH66705/MH/NIMH NIH HHS; NS049465/NS/NINDS NIH HHS; NS36519/NS/NINDS NIH HHS
Comments/Corrections

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