Document Detail


Whole-brain T2 mapping demonstrates occult abnormalities in focal epilepsy.
MedLine Citation:
PMID:  15668431     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To examine the cerebral structure of 14 patients with partial seizures and acquired lesions, 20 patients with malformations of cortical development (MCDs), and 45 patients with partial seizures and normal conventional MRI using whole-brain T2 mapping and statistical parametric mapping (SPM).
METHODS: T2 maps were calculated, and individual patients were compared with a group of 30 control subjects using SPM.
RESULTS: T2 mapping and objective voxel-by-voxel statistical comparison identified regions of increased T2 signal in all 14 patients with acquired nonprogressive cerebral lesions and partial seizures. In all of these, the areas of increased T2 signal concurred with abnormalities identified on visual inspection of conventional MRI. In 18 of 20 patients with MCDs, SPM detected regions of increased T2 signal, all of which corresponded to abnormalities identified on visual inspection of conventional MRI. In addition, in both groups, there were areas that were normal on conventional imaging, which demonstrated abnormal T2 signal. Voxel-by-voxel statistical analysis identified increased T2 signal in 23 of the 45 patients with cryptogenic focal epilepsy. In 20 of these, the areas of increased T2 signal concurred with epileptiform EEG abnormality and clinical seizure semiology. Group analysis of MRI-negative patients with electroclinical seizure onset localizing to the left and right temporal and left and right frontal regions revealed increased T2 signal within the white matter of each respective lobe.
CONCLUSIONS: T2 mapping analyzed using statistical parametric mapping was sensitive in patients with malformations of cortical development and acquired cerebral damage. Increased T2 signal in individual and grouped MRI-negative patients suggests that minor structural abnormalities exist in occult epileptogenic cerebral lesions.
Authors:
F J Rugg-Gunn; P A Boulby; M R Symms; G J Barker; J S Duncan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  64     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-25     Completed Date:  2005-09-20     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  318-25     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Water
Brain Mapping
Brain Neoplasms / complications
Cerebral Infarction / complications
Electroencephalography
Epilepsies, Partial / etiology,  pathology*
Female
Humans
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Neocortex / abnormalities,  chemistry,  pathology*
Teratoma / complications
Grant Support
ID/Acronym/Agency:
G9805989//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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