Document Detail

Whole-body section fluorescence imaging--a novel method for tissue distribution studies of fluorescent substances.
MedLine Citation:
PMID:  19142979     Owner:  NLM     Status:  MEDLINE    
The present study demonstrates the usefulness of whole body section fluorescence imaging, a novel technique used in optical imaging drug discovery. This method is in principle an analog of whole body autoradiography, except that fluorescence is measured instead of radioactivity. The method was shown to have a linear concentration-response relationship over a 1000-fold concentration range. Densitometric image analysis allowed semiquantitative studies of drug disposition and selective tumor retention of an optical imaging drug candidate.
Siver Moestue; Paula Nunez; Andrew Healey; Roger Bjerke; Bård Indrevoll; Tore Skotland; Svein Olaf Hustvedt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contrast media & molecular imaging     Volume:  4     ISSN:  1555-4317     ISO Abbreviation:  Contrast Media Mol Imaging     Publication Date:    2009 Mar-Apr
Date Detail:
Created Date:  2009-04-09     Completed Date:  2009-06-16     Revised Date:  2010-10-29    
Medline Journal Info:
Nlm Unique ID:  101286760     Medline TA:  Contrast Media Mol Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-80     Citation Subset:  IM    
Research and Development, GE Healthcare, Nycoveien 2, N-0401 Oslo, Norway.
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MeSH Terms
Autoradiography / methods*
Diagnostic Imaging / methods*
Mice, Inbred BALB C
Mice, Nude
Tissue Distribution
Whole-Body Counting / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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