Document Detail


Whole-body screening of atherosclerosis with magnetic resonance angiography.
MedLine Citation:
PMID:  18025987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With whole-body magnetic resonance angiography (WBMRA), it is possible to examine the whole arterial tree except intracranial and coronary vessels in a single examination without the risks involved in ionizing radiation or arterial cannulation. Whole-body magnetic resonance angiography is well suited for repeated clinical examinations in patients with systemic diseases such as vasculitis or atherosclerosis and can also be used for scientific purposes. On the basis of the WBMRA overview, a possible further development of the WBMRA concept can be to perform further acquisitions at sites with atherosclerotic plaques with higher-resolution scans to determine the degree of stenosis more accurately or to achieve plaque characterization. A total validation of WBMRA compared with digital subtraction angiography (DSA) is not possible owing to the hazards of ionizing radiation. Studies have shown a high sensitivity and specificity for the pelvic and lower limb arteries in comparison with DSA. No systematic validation against DSA has been performed for the renal, aortic, and carotid arteries. Various methods have been used, however, for confirmation of vascular abnormalities found on WBMRA such as ultrasonography, dedicated MRA, or DSA, with reasonably high agreement. The WBMRA method has not been studied with regard to prediction of future cardiovascular (CV) events, as have intima media thickness, coronary artery calcium scoring, and the ankle-brachial index. The full usefulness of WBMRA in an epidemiological setting and as a complementary screening tool for assessing CV risk still needs to be validated against future CV events.
Authors:
Tomas Hansen; Håkan Ahlström; Lars Johansson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Topics in magnetic resonance imaging : TMRI     Volume:  18     ISSN:  0899-3459     ISO Abbreviation:  Top Magn Reson Imaging     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913523     Medline TA:  Top Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  329-37     Citation Subset:  IM    
Affiliation:
Department of Radiology, Uppsala University Hospital, Uppsala, Sweden. tomas.hansen@radiol.uu.se
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MeSH Terms
Descriptor/Qualifier:
Atherosclerosis / diagnosis*
Contrast Media
Humans
Magnetic Resonance Angiography / methods*
Risk Assessment
Risk Factors
Sensitivity and Specificity
Whole Body Imaging / methods*
Chemical
Reg. No./Substance:
0/Contrast Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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