Document Detail


Whole body and regional fuel metabolism during early postexercise recovery.
MedLine Citation:
PMID:  2643339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied whole body and regional fuel metabolism 1-4 h after cycle exercise [70% maximum O2 consumption (VO2max)], using the insulin clamp technique (40 mU.M-2.min-1) with indirect calorimetry. Substrate fluxes were determined in nonexercised (forearm) muscle tissues. Total glucose utilization was not increased by exercise, either in the preinsulin or insulin-stimulated state. Glucose oxidation tended to decrease, and lipid oxidation was increased after exercise. Forearm glucose uptake (FGU) was increased 5 times by insulin in the resting state, due largely to increased fractional extraction (P less than 0.05). After exercise, FGU was not increased by insulin. Forearm alanine and lactate release was doubled 2 h after exercise. Branched-chain amino acid (BCAA) concentrations were increasing after exercise (P less than 0.01) at a time when forearm muscle was taking up these amino acids. Insulin infusion suppressed the elevated release of gluconeogenic precursors from the forearm and suppressed the elevated concentrations of BCAAs, free fatty acids, and glycerol present after exercise. In summary, basal and insulin-stimulated glucose utilization is not augmented by prior high-intensity exercise, partly because nonexercised muscle is insulin resistant. Insulin infusion attenuates the altered metabolic milieu seen during early recovery.
Authors:
J T Devlin; J Barlow; E S Horton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  256     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-21     Completed Date:  1989-02-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E167-72     Citation Subset:  IM    
Affiliation:
Metabolism-Endocrinology Unit, University of Vermont College of Medicine, Burlington 05405.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alanine / blood
Amino Acids, Branched-Chain / blood
Blood Glucose / metabolism
Calorimetry, Indirect
Energy Metabolism*
Exercise*
Fatty Acids, Nonesterified / blood
Female
Glucose / metabolism
Glycerol / blood
Humans
Insulin / administration & dosage,  pharmacology,  physiology
Lactates / blood
Lactic Acid
Lipid Metabolism
Male
Muscles
Norepinephrine / blood
Oxidation-Reduction
Oxygen Consumption
Pyruvates / blood
Pyruvic Acid
Grant Support
ID/Acronym/Agency:
K08-01554-01//PHS HHS
Chemical
Reg. No./Substance:
0/Amino Acids, Branched-Chain; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Lactates; 0/Pyruvates; 11061-68-0/Insulin; 127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 50-99-7/Glucose; 51-41-2/Norepinephrine; 56-41-7/Alanine; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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