| Whole body and regional fuel metabolism during early postexercise recovery. | |
| | |
MedLine Citation:
|
PMID: 2643339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We studied whole body and regional fuel metabolism 1-4 h after cycle exercise [70% maximum O2 consumption (VO2max)], using the insulin clamp technique (40 mU.M-2.min-1) with indirect calorimetry. Substrate fluxes were determined in nonexercised (forearm) muscle tissues. Total glucose utilization was not increased by exercise, either in the preinsulin or insulin-stimulated state. Glucose oxidation tended to decrease, and lipid oxidation was increased after exercise. Forearm glucose uptake (FGU) was increased 5 times by insulin in the resting state, due largely to increased fractional extraction (P less than 0.05). After exercise, FGU was not increased by insulin. Forearm alanine and lactate release was doubled 2 h after exercise. Branched-chain amino acid (BCAA) concentrations were increasing after exercise (P less than 0.01) at a time when forearm muscle was taking up these amino acids. Insulin infusion suppressed the elevated release of gluconeogenic precursors from the forearm and suppressed the elevated concentrations of BCAAs, free fatty acids, and glycerol present after exercise. In summary, basal and insulin-stimulated glucose utilization is not augmented by prior high-intensity exercise, partly because nonexercised muscle is insulin resistant. Insulin infusion attenuates the altered metabolic milieu seen during early recovery. |
| | |
Authors:
|
J T Devlin; J Barlow; E S Horton |
Related Documents
:
|
16921609 - Blood glucose changes in diabetic children and adolescents engaged in most common sport... 11093919 - Mechanisms underlying impaired glut-4 translocation in glycogen-supercompensated muscle... 2312459 - Skeletal muscle plasma membrane glucose transport and glucose transporters after exercise. 19568199 - Two bouts of exercise before meals, but not after meals, lower fasting blood glucose. 20473219 - Exercise and glycemic imbalances: a situation-specific estimate of glucose supplement. 1889269 - Diastolic time in diabetes. impairment of diastolic time during dynamic exercise in typ... 23190199 - Dose-response effect of exercise frequency on bone mineral density in post-menopausal, ... 15279079 - Relationship between insulin resistance assessed by homa-ir and exercise test variables... 7199849 - Reduction of hypoxic ventilatory drive by dopamine. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of physiology Volume: 256 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1989 Jan |
Date Detail:
|
Created Date: 1989-02-21 Completed Date: 1989-02-21 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: E167-72 Citation Subset: IM |
Affiliation:
|
Metabolism-Endocrinology Unit, University of Vermont College of Medicine, Burlington 05405. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alanine / blood Amino Acids, Branched-Chain / blood Blood Glucose / metabolism Calorimetry, Indirect Energy Metabolism* Exercise* Fatty Acids, Nonesterified / blood Female Glucose / metabolism Glycerol / blood Humans Insulin / administration & dosage, pharmacology, physiology Lactates / blood Lactic Acid Lipid Metabolism Male Muscles Norepinephrine / blood Oxidation-Reduction Oxygen Consumption Pyruvates / blood Pyruvic Acid |
| Grant Support | |
ID/Acronym/Agency:
|
K08-01554-01//PHS HHS |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids, Branched-Chain; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Lactates; 0/Pyruvates; 11061-68-0/Insulin; 127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 50-99-7/Glucose; 51-41-2/Norepinephrine; 56-41-7/Alanine; 56-81-5/Glycerol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fasting and postabsorptive hepatic glucose and insulin metabolism in hyperthyroidism.
Next Document: alpha-Glycerophosphate shuttle in a clonal beta-cell line.